Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy

Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy

Abstract Introduction The CRISPR/Cas9 system-based gene therapy can fundamentally address the issues of cancer occurrence, development, progression, and metastasis. However, the lack of targeting and effectiveness hinders gene therapy from entering clinical application. Herein, a somatostatin recept...

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Bibliographic Details
Main Authors: Suqin Zhang, Meng Li, Jingyi Zeng, Songli Zhou, Feifan Yue, Zhaoyi Chen, Lixin Ma, Yang Wang, Fei Wang, Jingwen Luo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Subjects:
Octreotide
Paclitaxel
PD-L1
Co-delivery
Ribonucleoprotein
Online Access:https://doi.org/10.1186/s12951-025-03214-3
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https://doi.org/10.1186/s12951-025-03214-3

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