Integrating genetics and transcriptomics to decipher susceptibility genes for risk stratification of gastric cancer and effect modification of Helicobacter pylori treatmentResearch in context

Integrating genetics and transcriptomics to decipher susceptibility genes for risk stratification of gastric cancer and effect modification of Helicobacter pylori treatmentResearch in context

Summary: Background: In a transcriptome-wide association study, we deciphered susceptibility genes that may predict gastric cancer (GC) risk and modify the effects of Helicobacter pylori (H. pylori) treatment. Methods: Genetically predicted expression models of 4518 genes were developed based on th...

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Bibliographic Details
Main Authors: Zhou-Yi Yin, Heng-Min Xu, Meng-Yuan Wang, Xin-Ling Wang, Zong-Chao Liu, Yu Jin, Yang Zhang, Jing-Ying Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EBioMedicine
Subjects:
Transcriptome-wide association study
Transcriptome risk score
Gastric cancer
Risk stratification
Primary prevention
Helicobacter pylori
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002117
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http://www.sciencedirect.com/science/article/pii/S2352396425002117

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