Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelatin for bone regeneration

Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelatin for bone regeneration

Highlights Layer-by-layer 3D-printing was effectively applied to prepare a biomimetic combined structure composing hard composite (PCL-nHA) and soft hydrogel (Alg-Gel). 3D-printing scaffolds were used to control the delivery of dexamethasone (DEX) to enhance bone repair. DEX-loaded scaffolds promote...

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Main Authors: Parastoo Noory, Ahmad Reza Farmani, Jafar Ai, Naghmeh Bahrami, Mohammad Bayat, Somayeh Ebrahimi-Barough, Ali Farzin, Shima Shojaie, Hamed Hajmoradi, Abdolreza Mohamadnia, Arash Goodarzi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Biological Engineering
Subjects:
3D printing
Layer-by-layer
Polycaprolactone
Nano-Hydroxyapatite
Alginate
Gelatin
Online Access:https://doi.org/10.1186/s13036-025-00514-y
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https://doi.org/10.1186/s13036-025-00514-y

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