Pulmonary hypertension associated with connective tissue disease
Pulmonary hypertension (PH) is an important cause of morbidity and mortality in connective tissue diseases (CTDs). CTDs may cause PH due to several mechanisms; pulmonary arterial hypertension, associated interstitial lung disease, neuromuscular disease, and/or sleep disordered breathing leading to h...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=1;spage=38;epage=47;aulast=Rajagopala |
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| _version_ | 1832569254637993984 |
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| author | Srinivas Rajagopala Molly Mary Thabah |
| author_facet | Srinivas Rajagopala Molly Mary Thabah |
| author_sort | Srinivas Rajagopala |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) is an important cause of morbidity and mortality in connective tissue diseases (CTDs). CTDs may cause PH due to several mechanisms; pulmonary arterial hypertension, associated interstitial lung disease, neuromuscular disease, and/or sleep disordered breathing leading to hypoxia, associated thromboembolic PH, and pulmonary venous hypertension due to left ventricular dysfunction. PH can be measured on echocardiography, but the gold standard for diagnosis is right heart catheterization. PH-specific therapy in addition to immunosuppression is the most common treatment used though data are scant. In this narrative review, we discuss the epidemiologic burden, clinical presentation, evaluation, and management of PH in CTDs. |
| format | Article |
| id | doaj-art-49af2fe7a36c4d01b13dfea705e549c4 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-49af2fe7a36c4d01b13dfea705e549c42025-02-02T22:45:22ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012017-01-01121384710.4103/0973-3698.199124Pulmonary hypertension associated with connective tissue diseaseSrinivas RajagopalaMolly Mary ThabahPulmonary hypertension (PH) is an important cause of morbidity and mortality in connective tissue diseases (CTDs). CTDs may cause PH due to several mechanisms; pulmonary arterial hypertension, associated interstitial lung disease, neuromuscular disease, and/or sleep disordered breathing leading to hypoxia, associated thromboembolic PH, and pulmonary venous hypertension due to left ventricular dysfunction. PH can be measured on echocardiography, but the gold standard for diagnosis is right heart catheterization. PH-specific therapy in addition to immunosuppression is the most common treatment used though data are scant. In this narrative review, we discuss the epidemiologic burden, clinical presentation, evaluation, and management of PH in CTDs.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=1;spage=38;epage=47;aulast=RajagopalaConnective tissue diseasemixed connective tissue diseaseprogressive systemic sclerosispulmonary hypertensionsystemic lupus erythrematosus |
| spellingShingle | Srinivas Rajagopala Molly Mary Thabah Pulmonary hypertension associated with connective tissue disease Indian Journal of Rheumatology Connective tissue disease mixed connective tissue disease progressive systemic sclerosis pulmonary hypertension systemic lupus erythrematosus |
| title | Pulmonary hypertension associated with connective tissue disease |
| title_full | Pulmonary hypertension associated with connective tissue disease |
| title_fullStr | Pulmonary hypertension associated with connective tissue disease |
| title_full_unstemmed | Pulmonary hypertension associated with connective tissue disease |
| title_short | Pulmonary hypertension associated with connective tissue disease |
| title_sort | pulmonary hypertension associated with connective tissue disease |
| topic | Connective tissue disease mixed connective tissue disease progressive systemic sclerosis pulmonary hypertension systemic lupus erythrematosus |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=1;spage=38;epage=47;aulast=Rajagopala |
| work_keys_str_mv | AT srinivasrajagopala pulmonaryhypertensionassociatedwithconnectivetissuedisease AT mollymarythabah pulmonaryhypertensionassociatedwithconnectivetissuedisease |