Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression

Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression

Summary: Doublecortin-like kinase 1 (Dclk1) expression identifies cells that are rare in normal pancreas but occur with an increased frequency in pancreatic neoplasia. The identity of these cells has been a matter of debate. We employed Dclk1 reporter mouse models and single-cell RNA sequencing (scR...

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Main Authors: Giovanni Valenti, Pasquale Laise, Feijing Wu, Ryota Takahashi, Tuo Ruan, Alessandro Vasciaveo, Zhengyu Jiang, Hiroki Kobayashi, Masaki Sunagawa, Moritz Middelhoff, Henrik Nienhüser, Na Fu, Ermanno Malagola, Osmel Companioni, Yoku Hayakawa, Alina C. Iuga, Andrea Califano, Timothy C. Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005054
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http://www.sciencedirect.com/science/article/pii/S2211124725005054

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