Combined impact of CHCHD10 p.Gly66Val and three other variants suggests oligogenic contributions to ALS

IntroductionAmyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease characterized by a progressive loss of motor neurons and muscle atrophy. Genetic factors are known to play important roles in ALS and concomitant presence of rare variants in ALS patients have been increasingly rep...

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Main Authors: YiYing Wang, YuXin Mi, Hui Wang, JingSi Jiang, Le Mao, YanXi Heng, XiaoGang Li, Min Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Neurology
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Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1438207/full
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