A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin
The favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing. However, the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxicity. Herein, a controlled/sustained release polyvinyl alcohol/chitosan/sulfonated...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-02-01
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| Series: | Journal of Bioresources and Bioproducts |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2369969824000732 |
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| author | Bowei Wang Dingkun Qiu Yihui Gu Zhu Shan Ruonan Shi Jing Luo Shuang Qi Yilin Wang Bo Jiang Yongcan Jin |
| author_facet | Bowei Wang Dingkun Qiu Yihui Gu Zhu Shan Ruonan Shi Jing Luo Shuang Qi Yilin Wang Bo Jiang Yongcan Jin |
| author_sort | Bowei Wang |
| collection | DOAJ |
| description | The favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing. However, the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxicity. Herein, a controlled/sustained release polyvinyl alcohol/chitosan/sulfonated lignin hydrogel (PVA-CS-L) integrated mechanical strengthening and bioactivities of lignin was developed. The lignin-induced non-covalent bond network (van der Waals force, hydrogen and electrostatic interactions) promoted energy dissipation when the hydrogel was subjected to stretching and compression. This endowed the PVA-CS-L hydrogel with improved tensile (∼36 kPa) and compressive strength (∼900 kPa), as well as compressive toughness (∼9.0 MJ/m3), which were superior to the polyvinyl alcohol/chitosan hydrogel (PVA-CS) (31 kPa, 680 kPa, and 7.5 MJ/m3, respectively). The construction of electrostatic interaction could not only slow down the sudden release of lignin but also make the hydrogel exhibit a good pH-sensitive behavior of controlled-release lignin. Also, the developed hydrogel had good biocompatibility and the released lignin had reactive oxygen species scavenging as well as inhibitory activity against Staphylococcus aureus. Finally, preliminary evaluation of drug delivery reveals that the presence of lignin enabled the hydrogel to exhibit longer-lasting controlled/sustained epigallocatechin gallate release properties. Such lignin-based controlled/sustained release hydrogel that integrates the molecular structure and biological difunctional features of lignin gives new insight into cost-effective, easy-to-operate manufacturing of load-bearing and bioactive materials. |
| format | Article |
| id | doaj-art-48cff381fc71452e8923f3079265e6f8 |
| institution | Kabale University |
| issn | 2369-9698 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Bioresources and Bioproducts |
| spelling | doaj-art-48cff381fc71452e8923f3079265e6f82025-01-26T05:04:10ZengKeAi Communications Co., Ltd.Journal of Bioresources and Bioproducts2369-96982025-02-011016276A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of ligninBowei Wang0Dingkun Qiu1Yihui Gu2Zhu Shan3Ruonan Shi4Jing Luo5Shuang Qi6Yilin Wang7Bo Jiang8Yongcan Jin9Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaCorresponding authors.; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaCorresponding authors.; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaThe favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing. However, the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxicity. Herein, a controlled/sustained release polyvinyl alcohol/chitosan/sulfonated lignin hydrogel (PVA-CS-L) integrated mechanical strengthening and bioactivities of lignin was developed. The lignin-induced non-covalent bond network (van der Waals force, hydrogen and electrostatic interactions) promoted energy dissipation when the hydrogel was subjected to stretching and compression. This endowed the PVA-CS-L hydrogel with improved tensile (∼36 kPa) and compressive strength (∼900 kPa), as well as compressive toughness (∼9.0 MJ/m3), which were superior to the polyvinyl alcohol/chitosan hydrogel (PVA-CS) (31 kPa, 680 kPa, and 7.5 MJ/m3, respectively). The construction of electrostatic interaction could not only slow down the sudden release of lignin but also make the hydrogel exhibit a good pH-sensitive behavior of controlled-release lignin. Also, the developed hydrogel had good biocompatibility and the released lignin had reactive oxygen species scavenging as well as inhibitory activity against Staphylococcus aureus. Finally, preliminary evaluation of drug delivery reveals that the presence of lignin enabled the hydrogel to exhibit longer-lasting controlled/sustained epigallocatechin gallate release properties. Such lignin-based controlled/sustained release hydrogel that integrates the molecular structure and biological difunctional features of lignin gives new insight into cost-effective, easy-to-operate manufacturing of load-bearing and bioactive materials.http://www.sciencedirect.com/science/article/pii/S2369969824000732LigninHydrogelControlled/sustained releaseMechanical strengtheningBioactivity |
| spellingShingle | Bowei Wang Dingkun Qiu Yihui Gu Zhu Shan Ruonan Shi Jing Luo Shuang Qi Yilin Wang Bo Jiang Yongcan Jin A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin Journal of Bioresources and Bioproducts Lignin Hydrogel Controlled/sustained release Mechanical strengthening Bioactivity |
| title | A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin |
| title_full | A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin |
| title_fullStr | A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin |
| title_full_unstemmed | A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin |
| title_short | A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin |
| title_sort | lignin based controlled sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin |
| topic | Lignin Hydrogel Controlled/sustained release Mechanical strengthening Bioactivity |
| url | http://www.sciencedirect.com/science/article/pii/S2369969824000732 |
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