Introduction of the hybcell-based compact sequencing technology and comparison to state-of-the-art methodologies for KRAS mutation detection

Introduction of the hybcell-based compact sequencing technology and comparison to state-of-the-art methodologies for KRAS mutation detection

The detection of KRAS mutations in codons 12 and 13 is critical for anti-EGFR therapy strategies; however, only those methodologies with high sensitivity, specificity, and accuracy as well as the best cost and turnaround balance are suitable for routine daily testing. Here we compared the performanc...

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Bibliographic Details
Main Authors: Agnes Zopf, Roman Raim, Martin Danzer, Norbert Niklas, Rita Spilka, Johannes Pröll, Christian Gabriel, Andreas Nechansky, Markus Roucka
Format: Article
Language:English
Published: Taylor & Francis Group 2015-03-01
Series:BioTechniques
Subjects:
KRAS
compact sequencing
Hyborg
hybcell technology
next-generation sequencing
Online Access:https://www.future-science.com/doi/10.2144/000114264
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https://www.future-science.com/doi/10.2144/000114264

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