Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter Study
Introduction: Pustular psoriasis (PP) is a rare life-threatening skin disease with negatively impact on quality of life (QoL). Clinically, it may be systemic (generalized pustular psoriasis [GPP]) or localized on palms and soles (palmoplantar pustulosis [PPP]). It is not rare to observe plaque psor...
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Mattioli1885
2025-01-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/4871 |
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| author | Dario Buononato Emanuele Scala Pierfrancesco Benvenuto Stefano Caccavale Eugenia Veronica Di Brizzi Roberta Di Caprio Giuseppe Argenziano Anna Balato |
| author_facet | Dario Buononato Emanuele Scala Pierfrancesco Benvenuto Stefano Caccavale Eugenia Veronica Di Brizzi Roberta Di Caprio Giuseppe Argenziano Anna Balato |
| author_sort | Dario Buononato |
| collection | DOAJ |
| description |
Introduction: Pustular psoriasis (PP) is a rare life-threatening skin disease with negatively impact on quality of life (QoL). Clinically, it may be systemic (generalized pustular psoriasis [GPP]) or localized on palms and soles (palmoplantar pustulosis [PPP]). It is not rare to observe plaque psoriasis associated with GPP.
Objective: We explored the therapies used for PP and their correlation with patient QoL scores, through a cross-sectional study using retrospective data from a monocentric database in the period 2017-2021.
Method: Patient characteristics were summarized using descriptive statistics and treatment predictors of QoL were identified by multiple regression analysis. Among 108 patients with PP, 57.4% had GPP + PSO whereas 42.6% had PPP. The therapeutic management is based on systemic conventional treatments and biological therapies in both GPP and PPP.
Results: GPP + PSO patients with an impaired QoL (DLQI≥10) were associated with biological therapy including certolizumab (OR=2.38), etanercept (OR=2.25), secukinumab (OR=2.03) or ustekinumab (OR=2.79) whereas, PPP patients were positively associated with secukinumab (OR=2.85) or apremilast (OR 4.28, 95%-CI 0.56-9.62).
Conclusion: Currently, systemic conventional therapy remains the therapeutic fulcrum of PP management. A great effect on QoL, especially for GPP+PSO, was assessed regardless the ongoing treatment and only newer biologic options were able to somehow positively impact.
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| format | Article |
| id | doaj-art-48c27db7e6f24ff8bbe17476a21bd0fc |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-48c27db7e6f24ff8bbe17476a21bd0fc2025-02-04T15:41:30ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-01-0115110.5826/dpc.1501a4871Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter StudyDario Buononato0Emanuele Scala1Pierfrancesco Benvenuto2Stefano Caccavale3Eugenia Veronica Di Brizzi4Roberta Di Caprio5Giuseppe Argenziano6Anna Balato7 Unit of Dermatology, University of Campania “Luigi Vanvitelli”, Naples, ItalyDivision of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden ; Department of Dermatology and Venereology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyUniversità degli studi della campania Luigi VanvitelliUniversità degli studi della campania Luigi VanvitelliUniversità degli studi della campania Luigi VanvitelliUniversità degli studi della campania Luigi VanvitelliUniversità degli studi della campania Luigi VanvitelliUniversità degli studi della campania Luigi Vanvitelli Introduction: Pustular psoriasis (PP) is a rare life-threatening skin disease with negatively impact on quality of life (QoL). Clinically, it may be systemic (generalized pustular psoriasis [GPP]) or localized on palms and soles (palmoplantar pustulosis [PPP]). It is not rare to observe plaque psoriasis associated with GPP. Objective: We explored the therapies used for PP and their correlation with patient QoL scores, through a cross-sectional study using retrospective data from a monocentric database in the period 2017-2021. Method: Patient characteristics were summarized using descriptive statistics and treatment predictors of QoL were identified by multiple regression analysis. Among 108 patients with PP, 57.4% had GPP + PSO whereas 42.6% had PPP. The therapeutic management is based on systemic conventional treatments and biological therapies in both GPP and PPP. Results: GPP + PSO patients with an impaired QoL (DLQI≥10) were associated with biological therapy including certolizumab (OR=2.38), etanercept (OR=2.25), secukinumab (OR=2.03) or ustekinumab (OR=2.79) whereas, PPP patients were positively associated with secukinumab (OR=2.85) or apremilast (OR 4.28, 95%-CI 0.56-9.62). Conclusion: Currently, systemic conventional therapy remains the therapeutic fulcrum of PP management. A great effect on QoL, especially for GPP+PSO, was assessed regardless the ongoing treatment and only newer biologic options were able to somehow positively impact. https://dpcj.org/index.php/dpc/article/view/4871generalized pustular psoriasispalmoplantar pustular pustulosisDLQIPsoriasisBiological Therapy |
| spellingShingle | Dario Buononato Emanuele Scala Pierfrancesco Benvenuto Stefano Caccavale Eugenia Veronica Di Brizzi Roberta Di Caprio Giuseppe Argenziano Anna Balato Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter Study Dermatology Practical & Conceptual generalized pustular psoriasis palmoplantar pustular pustulosis DLQI Psoriasis Biological Therapy |
| title | Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter Study |
| title_full | Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter Study |
| title_fullStr | Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter Study |
| title_full_unstemmed | Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter Study |
| title_short | Real-Life Analysis of Therapeutic Management and Its Correlation With the Dermatology Life Quality Index Score in 108 Patients With Pustular Psoriasis: An Italian Monocenter Study |
| title_sort | real life analysis of therapeutic management and its correlation with the dermatology life quality index score in 108 patients with pustular psoriasis an italian monocenter study |
| topic | generalized pustular psoriasis palmoplantar pustular pustulosis DLQI Psoriasis Biological Therapy |
| url | https://dpcj.org/index.php/dpc/article/view/4871 |
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