Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations
A simple, reliable, and sensitive kinetic spectrophotometric method was developed for determination of eight cephalosporin antibiotics, namely, Cefotaxime sodium, Cephapirin sodium, Cephradine dihydrate, Cephalexin monohydrate, Ceftazidime pentahydrate, Cefazoline sodium, Ceftriaxone sodium, and Cef...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/596379 |
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| author | Mahmoud A. Omar Osama H. Abdelmageed Tamer Z. Attia |
| author_facet | Mahmoud A. Omar Osama H. Abdelmageed Tamer Z. Attia |
| author_sort | Mahmoud A. Omar |
| collection | DOAJ |
| description | A simple, reliable, and sensitive kinetic spectrophotometric method was developed for determination of eight cephalosporin antibiotics, namely, Cefotaxime sodium, Cephapirin sodium, Cephradine dihydrate, Cephalexin monohydrate, Ceftazidime pentahydrate, Cefazoline sodium, Ceftriaxone sodium, and Cefuroxime sodium. The method depends on oxidation of each of studied drugs with alkaline potassium permanganate. The reaction is followed spectrophotometrically by measuring the rate of change of absorbance at 610 nm. The initial rate and fixed time (at 3 minutes) methods are utilized for construction of calibration graphs to determine the concentration of the studied drugs. The calibration graphs are linear in the concentration ranges 5–15 𝜇g mL−1 and 5–25 𝜇g mL−1 using the initial rate and fixed time methods, respectively. The results are validated statistically and checked through recovery studies. The method has been successfully applied for the determination of the studied cephalosporins in commercial dosage forms. Statistical comparisons of the results with the reference methods show the excellent agreement and indicate no significant difference in accuracy and precision. |
| format | Article |
| id | doaj-art-48a5c0bd35e64cd290e7a6f2df4077e1 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-48a5c0bd35e64cd290e7a6f2df4077e12025-02-03T05:44:25ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792009-01-01200910.1155/2009/596379596379Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical FormulationsMahmoud A. Omar0Osama H. Abdelmageed1Tamer Z. Attia2Analytical Chemistry Department, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptA simple, reliable, and sensitive kinetic spectrophotometric method was developed for determination of eight cephalosporin antibiotics, namely, Cefotaxime sodium, Cephapirin sodium, Cephradine dihydrate, Cephalexin monohydrate, Ceftazidime pentahydrate, Cefazoline sodium, Ceftriaxone sodium, and Cefuroxime sodium. The method depends on oxidation of each of studied drugs with alkaline potassium permanganate. The reaction is followed spectrophotometrically by measuring the rate of change of absorbance at 610 nm. The initial rate and fixed time (at 3 minutes) methods are utilized for construction of calibration graphs to determine the concentration of the studied drugs. The calibration graphs are linear in the concentration ranges 5–15 𝜇g mL−1 and 5–25 𝜇g mL−1 using the initial rate and fixed time methods, respectively. The results are validated statistically and checked through recovery studies. The method has been successfully applied for the determination of the studied cephalosporins in commercial dosage forms. Statistical comparisons of the results with the reference methods show the excellent agreement and indicate no significant difference in accuracy and precision.http://dx.doi.org/10.1155/2009/596379 |
| spellingShingle | Mahmoud A. Omar Osama H. Abdelmageed Tamer Z. Attia Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations International Journal of Analytical Chemistry |
| title | Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations |
| title_full | Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations |
| title_fullStr | Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations |
| title_full_unstemmed | Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations |
| title_short | Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations |
| title_sort | kinetic spectrophotometric determination of certain cephalosporins in pharmaceutical formulations |
| url | http://dx.doi.org/10.1155/2009/596379 |
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