A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

Abstract Parkinson’s disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of patients. Passive immunotherapy targeting these aggr...

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Main Authors: Sungwon An, John J. McInnis, Dongin Kim, Yihang Li, Ozge Tasdemir-Yilmaz, Jinhyung Ahn, Brian C. Mackness, Seung-Hwan Kwon, Julia Maeve Bonner, Miran Yoo, Simon Dujardin, Donghwan Kim, Jinyoung Park, Hyesu Yun, Yi Tang, Laurent Pradier, Sumin Hyeon, Daehae Song, Byungje Sung, Rajaraman Krishnan, Brian Spencer, Robert A. Rissman, Jagdeep K. Sandhu, Arsalan S. Haqqani, Jung-Won Shin, Donghwan B. Kim, Hyeran Lee, Jinwon Jung, Weon-Kyoo You, Alexandra T. Star, Christie E. Delaney, Danica B. Stanimirovic, Sergio Pablo Sardi, Sang Hoon Lee, Can Kayatekin
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01117-6
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https://doi.org/10.1038/s41531-025-01117-6

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