The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes Mellitus
Objectives. This cross-sectional study investigated the influence of clinically diagnosed neuropathy (cdNP) on respiratory muscle strength in patients with type 2 diabetes mellitus (T2DM). Methods. 110 T2DM patients and 35 nondiabetic healthy controls (≥60 years) were allocated to one of three group...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8065938 |
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| author | Birgit L. M. Van Eetvelde Dirk Cambier Karsten Vanden Wyngaert Bert Celie Patrick Calders |
| author_facet | Birgit L. M. Van Eetvelde Dirk Cambier Karsten Vanden Wyngaert Bert Celie Patrick Calders |
| author_sort | Birgit L. M. Van Eetvelde |
| collection | DOAJ |
| description | Objectives. This cross-sectional study investigated the influence of clinically diagnosed neuropathy (cdNP) on respiratory muscle strength in patients with type 2 diabetes mellitus (T2DM). Methods. 110 T2DM patients and 35 nondiabetic healthy controls (≥60 years) were allocated to one of three groups depending on the presence of cdNP: T2DM without cdNP (D−; n=28), T2DM with cdNP (D+; n=82), and controls without cdNP (C; n=35). Clinical neurological diagnostic examination consisted of Vibration Perception Threshold and Diabetic Neuropathy Symptom score. Respiratory muscle strength was registered by maximal Inspiratory and Expiratory Pressures (PImax and PEmax), and respiratory function by Peak Expiratory Flow (PEF). Isometric Handgrip Strength and Short Physical Performance Battery were used to evaluate peripheral skeletal muscle strength and physical performance. Univariate analysis of covariance was used with age, level of physical activity, and body mass index as covariates. Results. PImax, PEmax, and PEF were higher in C compared to D− and D+. Exploring more in detail, PImax, PEmax, and PEF were significantly lower in D+ compared to C. PEmax and PEF were also significantly lower in D− versus C. Measures of peripheral muscle strength and physical performance showed less associations with cdNP and T2DM. Conclusions. The presence of cdNP affects respiratory muscle strength in T2DM patients compared to healthy controls. Both cdNP and diabetes in themselves showed a distinctive impact on respiratory muscle strength and function; however, an accumulating effect could not be ascertained in this study. As commonly used measures of peripheral muscle strength and physical performance seemed to be less affected at the given time, the integration of PImax, PEmax, and PEF measurements in the assessment of respiratory muscle weakness could be of added value in the (early) screening for neuropathy in patients with T2DM. |
| format | Article |
| id | doaj-art-486068d1185f41cbbef487fa6843dfed |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-486068d1185f41cbbef487fa6843dfed2025-02-03T01:26:16ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/80659388065938The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes MellitusBirgit L. M. Van Eetvelde0Dirk Cambier1Karsten Vanden Wyngaert2Bert Celie3Patrick Calders4Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, BelgiumDepartment of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, BelgiumObjectives. This cross-sectional study investigated the influence of clinically diagnosed neuropathy (cdNP) on respiratory muscle strength in patients with type 2 diabetes mellitus (T2DM). Methods. 110 T2DM patients and 35 nondiabetic healthy controls (≥60 years) were allocated to one of three groups depending on the presence of cdNP: T2DM without cdNP (D−; n=28), T2DM with cdNP (D+; n=82), and controls without cdNP (C; n=35). Clinical neurological diagnostic examination consisted of Vibration Perception Threshold and Diabetic Neuropathy Symptom score. Respiratory muscle strength was registered by maximal Inspiratory and Expiratory Pressures (PImax and PEmax), and respiratory function by Peak Expiratory Flow (PEF). Isometric Handgrip Strength and Short Physical Performance Battery were used to evaluate peripheral skeletal muscle strength and physical performance. Univariate analysis of covariance was used with age, level of physical activity, and body mass index as covariates. Results. PImax, PEmax, and PEF were higher in C compared to D− and D+. Exploring more in detail, PImax, PEmax, and PEF were significantly lower in D+ compared to C. PEmax and PEF were also significantly lower in D− versus C. Measures of peripheral muscle strength and physical performance showed less associations with cdNP and T2DM. Conclusions. The presence of cdNP affects respiratory muscle strength in T2DM patients compared to healthy controls. Both cdNP and diabetes in themselves showed a distinctive impact on respiratory muscle strength and function; however, an accumulating effect could not be ascertained in this study. As commonly used measures of peripheral muscle strength and physical performance seemed to be less affected at the given time, the integration of PImax, PEmax, and PEF measurements in the assessment of respiratory muscle weakness could be of added value in the (early) screening for neuropathy in patients with T2DM.http://dx.doi.org/10.1155/2018/8065938 |
| spellingShingle | Birgit L. M. Van Eetvelde Dirk Cambier Karsten Vanden Wyngaert Bert Celie Patrick Calders The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes Mellitus Journal of Diabetes Research |
| title | The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes Mellitus |
| title_full | The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes Mellitus |
| title_fullStr | The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes Mellitus |
| title_short | The Influence of Clinically Diagnosed Neuropathy on Respiratory Muscle Strength in Type 2 Diabetes Mellitus |
| title_sort | influence of clinically diagnosed neuropathy on respiratory muscle strength in type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2018/8065938 |
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