Targeting p53-p21 signaling to enhance mesenchymal stem cell regenerative potential

Targeting p53-p21 signaling to enhance mesenchymal stem cell regenerative potential

Mesenchymal stem cells (MSCs) are properties of self-renewal and differentiation potentials and thus are very appealing to regenerative medicine. Nevertheless, their therapeutic potential is frequently constrained by senescence, limited proliferation, and stress-induced apoptosis. The key role of th...

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Bibliographic Details
Main Authors: Ahsas Goyal, Muhammad Afzal, Nawaid Hussain Khan, Kavita Goyal, Suresh Kumar Srinivasamurthy, Gaurav Gupta, K. Benod Kumar, Haider Ali, Mohit Rana, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Regenerative Therapy
Subjects:
Mesenchymal stem cells
p53-p21 signaling
Senescence
Proliferation
Apoptosis
Regenerative medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320425000616
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