Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment

Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment

Abstract High-grade serous ovarian cancer (HGSOC) is marked by significant molecular diversity, presenting a major clinical challenge due to its aggressive nature and poor prognosis. This study aims to deepen the understanding of HGSOC by characterizing mRNA subtypes and examining their immune micro...

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Bibliographic Details
Main Authors: Kaylin M. Carey, Corey D. Young, Alexis J. Clark, Eric B. Dammer, Rajesh Singh, James W. Lillard
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Ovarian Research
Subjects:
High-grade serous ovarian cancer
Immune microenvironment
Transcriptomic subtypes
Gene expression
Patient outcomes
Online Access:https://doi.org/10.1186/s13048-024-01556-4
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https://doi.org/10.1186/s13048-024-01556-4

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