Cost-effectiveness of de-escalated molecular subtype dependent use of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer in a Swedish setting

Cost-effectiveness of de-escalated molecular subtype dependent use of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer in a Swedish setting

BackgroundGuidelines recommend neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Current recommendations do not consider genomic profiles, although the Basal/Squamous (Ba/Sq) subtype is less likely to respond to NAC compared to Urothelial-like (Uro...

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Bibliographic Details
Main Authors: Sanjib Saha, Ulf-Göran Gerdtham, Gottfrid Sjödahl, Christel Häggström, James W. F. Catto, John D. Kelly, Anders Ullén, Lars Holmberg, Fredrik Liedberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
cost-effectiveness analysis
muscle invasive bladder cancer
molecular subtype
neoadjuvant chemotherapy
radical cystectomy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1556881/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1556881/full

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