CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death

CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death

Abstract Coxiella burnetii (Cb), the causative agent of Q fever, replicates within host macrophages by modulating immune responses through poorly understood mechanisms. Long non-coding RNAs (lncRNAs) are crucial yet underexplored regulators of inflammation, particularly in Cb pathogenesis. Employing...

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Main Authors: Aryashree Arunima, Seyednami Niyakan, Samantha M. Butler, Sabrina D. Clark, Anna Pinson, Doyoung Kwak, Elizabeth Di Russo Case, Xiaoning Qian, Paul de Figueiredo, Erin J. van Schaik, James E. Samuel
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62762-2
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https://doi.org/10.1038/s41467-025-62762-2

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