Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies
The neurotoxic effects of fungal toxins in both humans and animals have been well documented. Fumonisin B1 (FB1), a mycotoxin produced by fungi of the Fusarium species, is the most toxic fumonisin variant whose neurotoxic effect is still being elucidated. This review highlights the biochemical aspec...
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Elsevier
2025-06-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000496 |
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| author | Blessing A. Obafemi Isaac A. Adedara Cássia Pereira Delgado Olabisi T. Obafemi Michael Aschner Joao B.T. Rocha |
| author_facet | Blessing A. Obafemi Isaac A. Adedara Cássia Pereira Delgado Olabisi T. Obafemi Michael Aschner Joao B.T. Rocha |
| author_sort | Blessing A. Obafemi |
| collection | DOAJ |
| description | The neurotoxic effects of fungal toxins in both humans and animals have been well documented. Fumonisin B1 (FB1), a mycotoxin produced by fungi of the Fusarium species, is the most toxic fumonisin variant whose neurotoxic effect is still being elucidated. This review highlights the biochemical aspects of FB1 neurotoxicity, such as its mechanisms of action as well as therapeutic strategies. Both in vitro and in vivo studies have demonstrated that alteration in sphingolipid metabolism is a major event in FB-induced neurotoxicity. Studies have also shown that neurotoxicity due to FB1 involves dysregulation of several biochemical events in the brain, such as induction of oxidative stress and inflammation, mitochondrial dysfunction and associated programmed cell death, inhibition of acetylcholinesterase and alteration of neurotransmitter levels, decreased activity of Na+K+ ATPase, as well as disruption of blood-brain barrier. This review highlights the potential public health effects of FB1-induced neurotoxicity and the need to limit human and animal exposure to FB1in order to prevent its neurotoxic effect. Moreover, it is hoped that this review would stimulate studies aimed at filling the current research gaps such as delineating the effect of FB1 on the blood-brain barrier and appropriate therapies for neurotoxicity caused by FB1. |
| format | Article |
| id | doaj-art-47c32a6812fe4f81b7be8f7dc81fda73 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-47c32a6812fe4f81b7be8f7dc81fda732025-02-02T05:27:36ZengElsevierToxicology Reports2214-75002025-06-0114101931Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategiesBlessing A. Obafemi0Isaac A. Adedara1Cássia Pereira Delgado2Olabisi T. Obafemi3Michael Aschner4Joao B.T. Rocha5Department of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences, Federal University of Santa Maria, Camobi, Santa Maria 97105-900, Brazil; Department of Medical Biochemistry, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria; Correspondence to: Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Brazil.Department of Food Science and Technology, Center of Rural Sciences, Federal University of Santa Maria, Camobi, Santa Maria, RS 97105-900, BrazilDepartment of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences, Federal University of Santa Maria, Camobi, Santa Maria 97105-900, BrazilDepartment of Life and Consumer Sciences, University of South Africa, Florida 1710 Johannesburg, South AfricaDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences, Federal University of Santa Maria, Camobi, Santa Maria 97105-900, BrazilThe neurotoxic effects of fungal toxins in both humans and animals have been well documented. Fumonisin B1 (FB1), a mycotoxin produced by fungi of the Fusarium species, is the most toxic fumonisin variant whose neurotoxic effect is still being elucidated. This review highlights the biochemical aspects of FB1 neurotoxicity, such as its mechanisms of action as well as therapeutic strategies. Both in vitro and in vivo studies have demonstrated that alteration in sphingolipid metabolism is a major event in FB-induced neurotoxicity. Studies have also shown that neurotoxicity due to FB1 involves dysregulation of several biochemical events in the brain, such as induction of oxidative stress and inflammation, mitochondrial dysfunction and associated programmed cell death, inhibition of acetylcholinesterase and alteration of neurotransmitter levels, decreased activity of Na+K+ ATPase, as well as disruption of blood-brain barrier. This review highlights the potential public health effects of FB1-induced neurotoxicity and the need to limit human and animal exposure to FB1in order to prevent its neurotoxic effect. Moreover, it is hoped that this review would stimulate studies aimed at filling the current research gaps such as delineating the effect of FB1 on the blood-brain barrier and appropriate therapies for neurotoxicity caused by FB1.http://www.sciencedirect.com/science/article/pii/S2214750025000496SphingolipidToxicokineticsMycotoxinAstrocytesBlood-brain barrier |
| spellingShingle | Blessing A. Obafemi Isaac A. Adedara Cássia Pereira Delgado Olabisi T. Obafemi Michael Aschner Joao B.T. Rocha Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies Toxicology Reports Sphingolipid Toxicokinetics Mycotoxin Astrocytes Blood-brain barrier |
| title | Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies |
| title_full | Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies |
| title_fullStr | Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies |
| title_full_unstemmed | Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies |
| title_short | Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies |
| title_sort | fumonisin b1 neurotoxicity preclinical evidence biochemical mechanisms and therapeutic strategies |
| topic | Sphingolipid Toxicokinetics Mycotoxin Astrocytes Blood-brain barrier |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000496 |
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