FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle

FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle

BackgroundDiabetic nephropathy (DN) is a prevalent global renal illness and one of the main causes of end-stage renal disease (ESRD). FGF21 has been shown to ameliorate diabetic nephropathy, and in addition FGF-21-treated mice impeded mitogenicity, whereas it is unclear whether FGF21 can influence D...

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Bibliographic Details
Main Authors: Yudie Zhang, Fan Wang, Chongyang Zhang, Fan Yao, Bin Zhang, Yongping Zhang, Xiaobo Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
FGF21
diabetic nephropathy
CDK1
cell cycle
glomerular filtration barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1500458/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1500458/full

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