Cholesterol metabolism regulator SREBP2 inhibits HBV replication via suppression of HBx nuclear translocation

Cholesterol metabolism regulator SREBP2 inhibits HBV replication via suppression of HBx nuclear translocation

The intricate link between cholesterol metabolism and host immune responses is well recognized, but the specific mechanisms by which cholesterol biosynthesis influences hepatitis B virus (HBV) replication remain unclear. In this study, we show that SREBP2, a key regulator of cholesterol metabolism,...

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Bibliographic Details
Main Authors: Fan Yang, Feng Hu, Hongxiao Song, Tie Li, Fengchao Xu, Jing Xu, Le Wang, Fei Wang, Yujia Zhu, Mian Huang, Yanli Gao, Min Rao, Haichun Ma, Guangyun Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
cholesterol metabolism
HBV replication
SREBP2
HBx
HBV - hepatitis B virus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519639/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519639/full

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