Plakoglobin: Role in Tumorigenesis and Metastasis
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin. As a component of both the adherens junctions and desmosomes, plakoglobin plays a pivotal role in the regulation of cell-cell adhesion. Furthermore, similar to β-catenin, plakoglobin is capable of par...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/189521 |
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| _version_ | 1832550348413206528 |
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| author | Zackie Aktary Manijeh Pasdar |
| author_facet | Zackie Aktary Manijeh Pasdar |
| author_sort | Zackie Aktary |
| collection | DOAJ |
| description | Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin. As a component of both the adherens junctions and desmosomes, plakoglobin plays a pivotal role in the regulation of cell-cell adhesion. Furthermore, similar to β-catenin, plakoglobin is capable of participating in cell signaling. However, unlike β-catenin that has well-documented oncogenic potential through its involvement in the Wnt signaling pathway, plakoglobin generally acts as a tumor/metastasis suppressor. The exact roles that plakoglobin plays during tumorigenesis and metastasis are not clear; however, recent evidence suggests that it may regulate gene expression, cell proliferation, apoptosis, invasion, and migration. In this paper, we describe plakoglobin, its discovery and characterization, its role in regulating cell-cell adhesion, and its signaling capabilities in regulation of tumorigenesis and metastasis. |
| format | Article |
| id | doaj-art-477496603d724e7ea966ab4d91458cbc |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-477496603d724e7ea966ab4d91458cbc2025-02-03T06:07:05ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/189521189521Plakoglobin: Role in Tumorigenesis and MetastasisZackie Aktary0Manijeh Pasdar1Department of Cell Biology, University of Alberta, Edmonton, AB, T6G 2H7, CanadaDepartment of Cell Biology, University of Alberta, Edmonton, AB, T6G 2H7, CanadaPlakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin. As a component of both the adherens junctions and desmosomes, plakoglobin plays a pivotal role in the regulation of cell-cell adhesion. Furthermore, similar to β-catenin, plakoglobin is capable of participating in cell signaling. However, unlike β-catenin that has well-documented oncogenic potential through its involvement in the Wnt signaling pathway, plakoglobin generally acts as a tumor/metastasis suppressor. The exact roles that plakoglobin plays during tumorigenesis and metastasis are not clear; however, recent evidence suggests that it may regulate gene expression, cell proliferation, apoptosis, invasion, and migration. In this paper, we describe plakoglobin, its discovery and characterization, its role in regulating cell-cell adhesion, and its signaling capabilities in regulation of tumorigenesis and metastasis.http://dx.doi.org/10.1155/2012/189521 |
| spellingShingle | Zackie Aktary Manijeh Pasdar Plakoglobin: Role in Tumorigenesis and Metastasis International Journal of Cell Biology |
| title | Plakoglobin: Role in Tumorigenesis and Metastasis |
| title_full | Plakoglobin: Role in Tumorigenesis and Metastasis |
| title_fullStr | Plakoglobin: Role in Tumorigenesis and Metastasis |
| title_full_unstemmed | Plakoglobin: Role in Tumorigenesis and Metastasis |
| title_short | Plakoglobin: Role in Tumorigenesis and Metastasis |
| title_sort | plakoglobin role in tumorigenesis and metastasis |
| url | http://dx.doi.org/10.1155/2012/189521 |
| work_keys_str_mv | AT zackieaktary plakoglobinroleintumorigenesisandmetastasis AT manijehpasdar plakoglobinroleintumorigenesisandmetastasis |