Preclinical characterization of an active immunotherapy targeting calcitonin gene-related peptide

Preclinical characterization of an active immunotherapy targeting calcitonin gene-related peptide

Abstract Background The success of passive immunotherapies targeting Calcitonin gene-related peptide (CGRP) for managing migraine has prompted our efforts towards developing an active immunotherapy that induces the production of endogenous antibodies against CGRP. Achieving efficacious antibody tite...

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Main Authors: Justin D. Boyd, Shixia Wang, Hsiao-Wen Lin, Yueh-Ting Hsieh, Yu Shuang Sun, Brett A. Thibodeaux, Hanxin Lu, Jaya Sahni, Jonathan Wiggins, Matthew S. Longo, Jeanne K. Brooks, Madeline M. Vroom, Yi-Pin Chang, Zhi Liu, Shuang Ding, Jean-Cosme Dodart
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00870-2
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https://doi.org/10.1038/s43856-025-00870-2

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