Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells
Blood monocytes are precursors of dendritic cells, macrophages, and osteoclasts. They are a heterogeneous cell population with differences in size, phenotype, and function. Although monocytes maintain several tissue-specific populations of immune cells in homeostasis, their contribution to populatio...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1475435 |
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| _version_ | 1832551730502434816 |
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| author | Sara Sprangers Teun J. de Vries Vincent Everts |
| author_facet | Sara Sprangers Teun J. de Vries Vincent Everts |
| author_sort | Sara Sprangers |
| collection | DOAJ |
| description | Blood monocytes are precursors of dendritic cells, macrophages, and osteoclasts. They are a heterogeneous cell population with differences in size, phenotype, and function. Although monocytes maintain several tissue-specific populations of immune cells in homeostasis, their contribution to populations of dendritic cells, macrophages, and osteoclasts is significantly increased in inflammation. Identification of a growing number of functionally different subsets of cells within populations of monocyte-derived immune cells has recently put monocyte heterogeneity into sharp focus. Here, we summarize recent findings in monocyte heterogeneity and their differentiation into dendritic cells, macrophages, and osteoclasts. We also discuss these advances in the context of the formation of functionally different monocyte-derived subsets of dendritic cells, macrophages, and osteoclasts. |
| format | Article |
| id | doaj-art-473b1836c8af48778d7450f0b690d29f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-473b1836c8af48778d7450f0b690d29f2025-02-03T06:00:43ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/14754351475435Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune CellsSara Sprangers0Teun J. de Vries1Vincent Everts2Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, NetherlandsDepartment of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, NetherlandsDepartment of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, NetherlandsBlood monocytes are precursors of dendritic cells, macrophages, and osteoclasts. They are a heterogeneous cell population with differences in size, phenotype, and function. Although monocytes maintain several tissue-specific populations of immune cells in homeostasis, their contribution to populations of dendritic cells, macrophages, and osteoclasts is significantly increased in inflammation. Identification of a growing number of functionally different subsets of cells within populations of monocyte-derived immune cells has recently put monocyte heterogeneity into sharp focus. Here, we summarize recent findings in monocyte heterogeneity and their differentiation into dendritic cells, macrophages, and osteoclasts. We also discuss these advances in the context of the formation of functionally different monocyte-derived subsets of dendritic cells, macrophages, and osteoclasts.http://dx.doi.org/10.1155/2016/1475435 |
| spellingShingle | Sara Sprangers Teun J. de Vries Vincent Everts Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells Journal of Immunology Research |
| title | Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells |
| title_full | Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells |
| title_fullStr | Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells |
| title_full_unstemmed | Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells |
| title_short | Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells |
| title_sort | monocyte heterogeneity consequences for monocyte derived immune cells |
| url | http://dx.doi.org/10.1155/2016/1475435 |
| work_keys_str_mv | AT sarasprangers monocyteheterogeneityconsequencesformonocytederivedimmunecells AT teunjdevries monocyteheterogeneityconsequencesformonocytederivedimmunecells AT vincenteverts monocyteheterogeneityconsequencesformonocytederivedimmunecells |