Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene
The aim of the research is to analyse the influence of polymorphisms of endothelin-1 gene and endothelin-1 receptor type A gene on the clinical condition of patients with primary open angle glaucoma. Methods. 285 Polish patients took part in the research (160 normal-tension glaucoma and 125 high-ten...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/368792 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545501858234368 |
|---|---|
| author | Dominika Wróbel-Dudzińska Ewa Kosior-Jarecka Urszula Łukasik Janusz Kocki Agnieszka Witczak Jerzy Mosiewicz Tomasz Żarnowski |
| author_facet | Dominika Wróbel-Dudzińska Ewa Kosior-Jarecka Urszula Łukasik Janusz Kocki Agnieszka Witczak Jerzy Mosiewicz Tomasz Żarnowski |
| author_sort | Dominika Wróbel-Dudzińska |
| collection | DOAJ |
| description | The aim of the research is to analyse the influence of polymorphisms of endothelin-1 gene and endothelin-1 receptor type A gene on the clinical condition of patients with primary open angle glaucoma. Methods. 285 Polish patients took part in the research (160 normal-tension glaucoma and 125 high-tension glaucoma). DNA was isolated by standard methods and genotype distributions of four polymorphisms in genes encoding endothelin-1 (K198N) and endothelin-1 receptor type A polymorphisms (C1222T, C70G, and G231A) were determined. Genotype distributions were compared between NTG and HTG groups. The clinical condition of participants was examined for association with polymorphisms. Results. A similar frequency of occurrence of the polymorphic varieties of the studied genes was observed in patients with NTG and HTG. There is no relation between NTG risk factors and examined polymorphisms. NTG patients with TT genotype of K198N polymorphism presented with the lowest intraocular pressure in comparison to GG + GT genotype (p=0.03). In NTG patients with CC genotype of C1222T polymorphism (p=0.028) and GG of C70G polymorphism (p=0.03) the lowest values of mean blood pressure were observed. Conclusions. The studied polymorphic varieties (K198N, C1222T) do have an influence on intraocular pressure as well as arterial blood pressure in NTG patients. |
| format | Article |
| id | doaj-art-46b7eab75ea1413fa85e7e568599c084 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-46b7eab75ea1413fa85e7e568599c0842025-02-03T07:25:40ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/368792368792Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A GeneDominika Wróbel-Dudzińska0Ewa Kosior-Jarecka1Urszula Łukasik2Janusz Kocki3Agnieszka Witczak4Jerzy Mosiewicz5Tomasz Żarnowski6Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Chmielna 1, 20-079 Lublin, PolandDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Chmielna 1, 20-079 Lublin, PolandDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Chmielna 1, 20-079 Lublin, PolandDepartment of Clinical Genetics, Medical University, Radziwiłłowska 11, 20-080 Lublin, PolandDepartment of Internal Diseases, Medical University, Staszica 16, 20-081 Lublin, PolandDepartment of Internal Diseases, Medical University, Staszica 16, 20-081 Lublin, PolandDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University, Chmielna 1, 20-079 Lublin, PolandThe aim of the research is to analyse the influence of polymorphisms of endothelin-1 gene and endothelin-1 receptor type A gene on the clinical condition of patients with primary open angle glaucoma. Methods. 285 Polish patients took part in the research (160 normal-tension glaucoma and 125 high-tension glaucoma). DNA was isolated by standard methods and genotype distributions of four polymorphisms in genes encoding endothelin-1 (K198N) and endothelin-1 receptor type A polymorphisms (C1222T, C70G, and G231A) were determined. Genotype distributions were compared between NTG and HTG groups. The clinical condition of participants was examined for association with polymorphisms. Results. A similar frequency of occurrence of the polymorphic varieties of the studied genes was observed in patients with NTG and HTG. There is no relation between NTG risk factors and examined polymorphisms. NTG patients with TT genotype of K198N polymorphism presented with the lowest intraocular pressure in comparison to GG + GT genotype (p=0.03). In NTG patients with CC genotype of C1222T polymorphism (p=0.028) and GG of C70G polymorphism (p=0.03) the lowest values of mean blood pressure were observed. Conclusions. The studied polymorphic varieties (K198N, C1222T) do have an influence on intraocular pressure as well as arterial blood pressure in NTG patients.http://dx.doi.org/10.1155/2015/368792 |
| spellingShingle | Dominika Wróbel-Dudzińska Ewa Kosior-Jarecka Urszula Łukasik Janusz Kocki Agnieszka Witczak Jerzy Mosiewicz Tomasz Żarnowski Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene Journal of Ophthalmology |
| title | Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene |
| title_full | Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene |
| title_fullStr | Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene |
| title_full_unstemmed | Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene |
| title_short | Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene |
| title_sort | risk factors in normal tension glaucoma and high tension glaucoma in relation to polymorphisms of endothelin 1 gene and endothelin 1 receptor type a gene |
| url | http://dx.doi.org/10.1155/2015/368792 |
| work_keys_str_mv | AT dominikawrobeldudzinska riskfactorsinnormaltensionglaucomaandhightensionglaucomainrelationtopolymorphismsofendothelin1geneandendothelin1receptortypeagene AT ewakosiorjarecka riskfactorsinnormaltensionglaucomaandhightensionglaucomainrelationtopolymorphismsofendothelin1geneandendothelin1receptortypeagene AT urszulałukasik riskfactorsinnormaltensionglaucomaandhightensionglaucomainrelationtopolymorphismsofendothelin1geneandendothelin1receptortypeagene AT januszkocki riskfactorsinnormaltensionglaucomaandhightensionglaucomainrelationtopolymorphismsofendothelin1geneandendothelin1receptortypeagene AT agnieszkawitczak riskfactorsinnormaltensionglaucomaandhightensionglaucomainrelationtopolymorphismsofendothelin1geneandendothelin1receptortypeagene AT jerzymosiewicz riskfactorsinnormaltensionglaucomaandhightensionglaucomainrelationtopolymorphismsofendothelin1geneandendothelin1receptortypeagene AT tomaszzarnowski riskfactorsinnormaltensionglaucomaandhightensionglaucomainrelationtopolymorphismsofendothelin1geneandendothelin1receptortypeagene |