Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A

Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A

Abstract Studies of laminopathy-based progeria offer insights into aging-associated diseases and highlight the role of LMNA in chromatin organization. Mandibuloacral dysplasia type A (MAD) is a largely unexplored form of atypical progeria that lacks lamin A post-translational processing defects. Usi...

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Main Authors: Wei Jin, Shaoshuai Jiang, Xinyi Liu, Yi He, Tuo Li, Jingchun Ma, Zhihong Chen, Xiaomei Lu, Xinguang Liu, Weinian Shou, Guoxiang Jin, Junjun Ding, Zhongjun Zhou
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54338-3
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https://doi.org/10.1038/s41467-024-54338-3

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