Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction
Diabetic foot ulcers are seriously endangering the physical and mental health of patients. Due to the long duration of inflammation, the treatment of nonhealing wounds in diabetes is one of the most prominent healthcare problems in the world. The nuclear factor kappa B (NF-κB) signaling pathway, a c...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2021/9709290 |
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| author | Xianyi Wang Wanqiu Li Shengdi Lu Zhongliang Ma |
| author_facet | Xianyi Wang Wanqiu Li Shengdi Lu Zhongliang Ma |
| author_sort | Xianyi Wang |
| collection | DOAJ |
| description | Diabetic foot ulcers are seriously endangering the physical and mental health of patients. Due to the long duration of inflammation, the treatment of nonhealing wounds in diabetes is one of the most prominent healthcare problems in the world. The nuclear factor kappa B (NF-κB) signaling pathway, a classical pathway that triggers inflammatory response, is regulated by many regulators, such as glycogen synthase kinase 3 beta (GSK-3β). Noncoding RNAs, a large class of molecules that regulate gene expression at the posttranscriptional or posttranslational level, play an important role in various stages of wound healing, especially in the stage of inflammation. Herein, we summarized the roles of noncoding RNAs in the NF-κB/GSK-3β signaling, which might provide new ideas for the treatment of diabetic wound healing. |
| format | Article |
| id | doaj-art-46303715b5c849c59f8df7e87d637ac6 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-46303715b5c849c59f8df7e87d637ac62025-02-03T01:24:47ZengWileyInternational Journal of Genomics2314-436X2314-43782021-01-01202110.1155/2021/97092909709290Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling InteractionXianyi Wang0Wanqiu Li1Shengdi Lu2Zhongliang Ma3Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaDepartment of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Xuhui District, Shanghai 200233, ChinaLab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, ChinaDiabetic foot ulcers are seriously endangering the physical and mental health of patients. Due to the long duration of inflammation, the treatment of nonhealing wounds in diabetes is one of the most prominent healthcare problems in the world. The nuclear factor kappa B (NF-κB) signaling pathway, a classical pathway that triggers inflammatory response, is regulated by many regulators, such as glycogen synthase kinase 3 beta (GSK-3β). Noncoding RNAs, a large class of molecules that regulate gene expression at the posttranscriptional or posttranslational level, play an important role in various stages of wound healing, especially in the stage of inflammation. Herein, we summarized the roles of noncoding RNAs in the NF-κB/GSK-3β signaling, which might provide new ideas for the treatment of diabetic wound healing.http://dx.doi.org/10.1155/2021/9709290 |
| spellingShingle | Xianyi Wang Wanqiu Li Shengdi Lu Zhongliang Ma Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction International Journal of Genomics |
| title | Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction |
| title_full | Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction |
| title_fullStr | Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction |
| title_full_unstemmed | Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction |
| title_short | Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction |
| title_sort | modulation of the wound healing through noncoding rna interplay and gsk 3β nf κb signaling interaction |
| url | http://dx.doi.org/10.1155/2021/9709290 |
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