Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study. FKS mutants carrying specific mutations found in L74 were reconstructed by the Alt-R CR...

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Main Authors: Xin Hou, Kelley R. Healey, Erika Shor, Milena Kordalewska, Cristina Jiménez Ortigosa, Padmaja Paderu, Meng Xiao, He Wang, Ying Zhao, Li-Yan Lin, Yan-Hai Zhang, Yong-Zhe Li, Ying-Chun Xu, David S. Perlin, Yanan Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Candida glabrata
FKS
echinocandin resistance
CRISPR-Cas9
resistance mechanism
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1684209
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https://www.tandfonline.com/doi/10.1080/22221751.2019.1684209

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