<i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors
<b>Background:</b> <i>Garcinia brasiliensis</i> is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from <i>G. brasiliensis</i> leaves on the ascitic (EA...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/1/24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587707003437056 |
|---|---|
| author | Lucas Sylvestre Silva Eduardo Cavallini Rafael André da Silva Monielle Sant’Ana Ariane Harumi Yoshikawa Thiago Salomão Bianca Huang Paula Craice Luiz Philipe de Souza Ferreira Heitor Pedro Della Matta Cristiane Damas Gil Maria de Lourdes Gomes Pereira Ana Paula Girol |
| author_facet | Lucas Sylvestre Silva Eduardo Cavallini Rafael André da Silva Monielle Sant’Ana Ariane Harumi Yoshikawa Thiago Salomão Bianca Huang Paula Craice Luiz Philipe de Souza Ferreira Heitor Pedro Della Matta Cristiane Damas Gil Maria de Lourdes Gomes Pereira Ana Paula Girol |
| author_sort | Lucas Sylvestre Silva |
| collection | DOAJ |
| description | <b>Background:</b> <i>Garcinia brasiliensis</i> is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from <i>G. brasiliensis</i> leaves on the ascitic (EA) and solid (ES) forms of Ehrlich tumors. <b>Methods</b>: Induced and uninduced BALB/c mice were treated intramuscularly, for 7 or 14 days, with saline solution or CE and EAF, both at a 10% concentration, based on in vitro cytotoxicity assessment. Biochemical analyses were also performed to evaluate in vivo cytotoxicity. In relation to tumor-induced animals, morphological changes, plasma enzymes, inflammatory mediators and the induction of apoptosis were analyzed, in addition to histopathological studies, to evaluate the inhibition of tumor growth. <b>Results</b>: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) were regulated by CE and EAF administration. Furthermore, both treatments were effective in inhibiting tumor growth in EA and ES by modulating the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α, decreasing mast cells numbers and inducing apoptosis. <b>Conclusions</b>: This research indicates that both CE and EAF from <i>G. brasiliensis</i> leaves have potential antitumor effects with low cytotoxicity. |
| format | Article |
| id | doaj-art-460638cc9c3c49b8ab8189f46981e2ef |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-460638cc9c3c49b8ab8189f46981e2ef2025-01-24T13:45:03ZengMDPI AGPharmaceuticals1424-82472024-12-011812410.3390/ph18010024<i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich TumorsLucas Sylvestre Silva0Eduardo Cavallini1Rafael André da Silva2Monielle Sant’Ana3Ariane Harumi Yoshikawa4Thiago Salomão5Bianca Huang6Paula Craice7Luiz Philipe de Souza Ferreira8Heitor Pedro Della Matta9Cristiane Damas Gil10Maria de Lourdes Gomes Pereira11Ana Paula Girol12Post Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, BrazilPost Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, BrazilDepartment of Biology, Institute of Biosciences, Humanities and Exact Sciences (Ibilce), São Paulo State University (UNESP), São José do Rio Preto 15054-000, SP, BrazilPost Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, BrazilExperimental and Clinical Research Center (CEPEC), Padre Albino University Center (UNIFIPA), Catanduva 15809-144, SP, BrazilExperimental and Clinical Research Center (CEPEC), Padre Albino University Center (UNIFIPA), Catanduva 15809-144, SP, BrazilExperimental and Clinical Research Center (CEPEC), Padre Albino University Center (UNIFIPA), Catanduva 15809-144, SP, BrazilExperimental and Clinical Research Center (CEPEC), Padre Albino University Center (UNIFIPA), Catanduva 15809-144, SP, BrazilPost Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, BrazilExperimental and Clinical Research Center (CEPEC), Padre Albino University Center (UNIFIPA), Catanduva 15809-144, SP, BrazilPost Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, BrazilCICECO-Aveiro Institute of Materials, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalPost Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, Brazil<b>Background:</b> <i>Garcinia brasiliensis</i> is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from <i>G. brasiliensis</i> leaves on the ascitic (EA) and solid (ES) forms of Ehrlich tumors. <b>Methods</b>: Induced and uninduced BALB/c mice were treated intramuscularly, for 7 or 14 days, with saline solution or CE and EAF, both at a 10% concentration, based on in vitro cytotoxicity assessment. Biochemical analyses were also performed to evaluate in vivo cytotoxicity. In relation to tumor-induced animals, morphological changes, plasma enzymes, inflammatory mediators and the induction of apoptosis were analyzed, in addition to histopathological studies, to evaluate the inhibition of tumor growth. <b>Results</b>: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) were regulated by CE and EAF administration. Furthermore, both treatments were effective in inhibiting tumor growth in EA and ES by modulating the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α, decreasing mast cells numbers and inducing apoptosis. <b>Conclusions</b>: This research indicates that both CE and EAF from <i>G. brasiliensis</i> leaves have potential antitumor effects with low cytotoxicity.https://www.mdpi.com/1424-8247/18/1/24<i>Garcinia brasiliensis</i>antitumorEhrlich tumorantioxidant |
| spellingShingle | Lucas Sylvestre Silva Eduardo Cavallini Rafael André da Silva Monielle Sant’Ana Ariane Harumi Yoshikawa Thiago Salomão Bianca Huang Paula Craice Luiz Philipe de Souza Ferreira Heitor Pedro Della Matta Cristiane Damas Gil Maria de Lourdes Gomes Pereira Ana Paula Girol <i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors Pharmaceuticals <i>Garcinia brasiliensis</i> antitumor Ehrlich tumor antioxidant |
| title | <i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors |
| title_full | <i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors |
| title_fullStr | <i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors |
| title_full_unstemmed | <i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors |
| title_short | <i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors |
| title_sort | i garcinia brasiliensis i leaves extracts inhibit the development of ascitic and solid ehrlich tumors |
| topic | <i>Garcinia brasiliensis</i> antitumor Ehrlich tumor antioxidant |
| url | https://www.mdpi.com/1424-8247/18/1/24 |
| work_keys_str_mv | AT lucassylvestresilva igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT eduardocavallini igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT rafaelandredasilva igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT moniellesantana igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT arianeharumiyoshikawa igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT thiagosalomao igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT biancahuang igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT paulacraice igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT luizphilipedesouzaferreira igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT heitorpedrodellamatta igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT cristianedamasgil igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT mariadelourdesgomespereira igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors AT anapaulagirol igarciniabrasiliensisileavesextractsinhibitthedevelopmentofasciticandsolidehrlichtumors |