Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC
A reverse phase HPLC method is described for the determination of Ziprasidone HCl mono hydrate in bulk and pharmaceutical dosage forms. Chromatography was carried out on an ODS C18 column using a mixture of methanol and phosphate buffer (55:45v/v) as the mobile phase at a flow rate of 1mL/min. Detec...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2006/252570 |
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| author | B. Sudha Rani P. Venkata Reddy |
| author_facet | B. Sudha Rani P. Venkata Reddy |
| author_sort | B. Sudha Rani |
| collection | DOAJ |
| description | A reverse phase HPLC method is described for the determination of Ziprasidone HCl mono hydrate in bulk and pharmaceutical dosage forms. Chromatography was carried out on an ODS C18 column using a mixture of methanol and phosphate buffer (55:45v/v) as the mobile phase at a flow rate of 1mL/min. Detection was carried out at 314nm. The retension time of the drug was 4.522 min. The method produced linear responses in the concentration range of 0.5-30 μg /mL of Ziprasidone HCl mono hydrate.The method was found to be applicable for determination of the drug in capsules. |
| format | Article |
| id | doaj-art-45e31d753e7547af9daea05a3e05e6a4 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-45e31d753e7547af9daea05a3e05e6a42025-02-03T06:41:57ZengWileyE-Journal of Chemistry0973-49452090-98102006-01-013316917210.1155/2006/252570Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLCB. Sudha Rani0P. Venkata Reddy1College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, IndiaCollege of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, IndiaA reverse phase HPLC method is described for the determination of Ziprasidone HCl mono hydrate in bulk and pharmaceutical dosage forms. Chromatography was carried out on an ODS C18 column using a mixture of methanol and phosphate buffer (55:45v/v) as the mobile phase at a flow rate of 1mL/min. Detection was carried out at 314nm. The retension time of the drug was 4.522 min. The method produced linear responses in the concentration range of 0.5-30 μg /mL of Ziprasidone HCl mono hydrate.The method was found to be applicable for determination of the drug in capsules.http://dx.doi.org/10.1155/2006/252570 |
| spellingShingle | B. Sudha Rani P. Venkata Reddy Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC E-Journal of Chemistry |
| title | Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC |
| title_full | Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC |
| title_fullStr | Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC |
| title_full_unstemmed | Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC |
| title_short | Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC |
| title_sort | estimation of ziprasidone hydrochloride monohydrate in bulk and capsules by reverse phase hplc |
| url | http://dx.doi.org/10.1155/2006/252570 |
| work_keys_str_mv | AT bsudharani estimationofziprasidonehydrochloridemonohydrateinbulkandcapsulesbyreversephasehplc AT pvenkatareddy estimationofziprasidonehydrochloridemonohydrateinbulkandcapsulesbyreversephasehplc |