Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma

Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma

BackgroundNorcantharidin (NCTD), a bioactive compound derived from traditional Chinese medicine, has demonstrated promising anticancer activity against multiple malignancies, particularly hepatocellular carcinoma (HCC). However, its epigenetic regulatory mechanisms and associated transcriptional con...

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Bibliographic Details
Main Authors: Ruibing Wu, Hengye Yuan, Yuehua Wang, Xianggang Gou, Wanhua Hou, Zhongzheng Zhou, Xinran Wang, Xiuling Deng, Changshan Wang, Haisheng Wang, Jia Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
NCTD
TOP2A
H3K27me3
EZH2
HCC
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1541298/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1541298/full

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