Skin Findings in a Patient with Sjogren’s Syndrome
Hypergammaglobulinemic purpura (HGP) is a syndrome constellating recurrent purpura, hypergammaglobulinemia, positive rheumatoid factor (RF), anti-Ro/La antibodies, and elevated erythrocyte sedimentation rate (ESR). We present a case of a 29-year-old female who was diagnosed with Sjogren’s syndrome f...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2016/4829459 |
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| author | Prajwal Boddu Abdul S. Mohammed Sonali Khandelwal |
| author_facet | Prajwal Boddu Abdul S. Mohammed Sonali Khandelwal |
| author_sort | Prajwal Boddu |
| collection | DOAJ |
| description | Hypergammaglobulinemic purpura (HGP) is a syndrome constellating recurrent purpura, hypergammaglobulinemia, positive rheumatoid factor (RF), anti-Ro/La antibodies, and elevated erythrocyte sedimentation rate (ESR). We present a case of a 29-year-old female who was diagnosed with Sjogren’s syndrome four years prior to presenting with rash on her lower extremities for a period of 6 months. Skin biopsy at the initial visit was consistent with leukocytoclastic vasculitis and was initiated on treatment for it. Her rash evolved into 2–5 mm scattered purpurae while she was on the treatment and a repeat biopsy showed extravasation of RBCs, a sparse mononuclear infiltrate with deposition of plasma cells, and no evidence of leukocytoclastic vasculitis, thus showing a transition from neutrophilic to mononuclear inflammatory vascular disease which is a rare occurrence. Hypergammaglobulinemic purpura sometimes turns out to be a challenging disease to manage and requires an integrated effort from the primary care doctors, rheumatologist, and dermatologist. |
| format | Article |
| id | doaj-art-45d898dff6644074a53fe5bb3957a88b |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-45d898dff6644074a53fe5bb3957a88b2025-02-03T07:24:59ZengWileyCase Reports in Rheumatology2090-68892090-68972016-01-01201610.1155/2016/48294594829459Skin Findings in a Patient with Sjogren’s SyndromePrajwal Boddu0Abdul S. Mohammed1Sonali Khandelwal2Advocate Illinois Masonic Medical Center, Department of Internal Medicine, 856 West Nelson Street, Apt No. 2002, Chicago, IL 60657, USAAdvocate Illinois Masonic Medical Center, Department of Internal Medicine, 2356 North Elston Avenue, No. 306, Chicago, IL 60614, USARUSH University Medical Center, Department of Rheumatology, 1725 West Harrison Street, Chicago, IL 60612, USAHypergammaglobulinemic purpura (HGP) is a syndrome constellating recurrent purpura, hypergammaglobulinemia, positive rheumatoid factor (RF), anti-Ro/La antibodies, and elevated erythrocyte sedimentation rate (ESR). We present a case of a 29-year-old female who was diagnosed with Sjogren’s syndrome four years prior to presenting with rash on her lower extremities for a period of 6 months. Skin biopsy at the initial visit was consistent with leukocytoclastic vasculitis and was initiated on treatment for it. Her rash evolved into 2–5 mm scattered purpurae while she was on the treatment and a repeat biopsy showed extravasation of RBCs, a sparse mononuclear infiltrate with deposition of plasma cells, and no evidence of leukocytoclastic vasculitis, thus showing a transition from neutrophilic to mononuclear inflammatory vascular disease which is a rare occurrence. Hypergammaglobulinemic purpura sometimes turns out to be a challenging disease to manage and requires an integrated effort from the primary care doctors, rheumatologist, and dermatologist.http://dx.doi.org/10.1155/2016/4829459 |
| spellingShingle | Prajwal Boddu Abdul S. Mohammed Sonali Khandelwal Skin Findings in a Patient with Sjogren’s Syndrome Case Reports in Rheumatology |
| title | Skin Findings in a Patient with Sjogren’s Syndrome |
| title_full | Skin Findings in a Patient with Sjogren’s Syndrome |
| title_fullStr | Skin Findings in a Patient with Sjogren’s Syndrome |
| title_full_unstemmed | Skin Findings in a Patient with Sjogren’s Syndrome |
| title_short | Skin Findings in a Patient with Sjogren’s Syndrome |
| title_sort | skin findings in a patient with sjogren s syndrome |
| url | http://dx.doi.org/10.1155/2016/4829459 |
| work_keys_str_mv | AT prajwalboddu skinfindingsinapatientwithsjogrenssyndrome AT abdulsmohammed skinfindingsinapatientwithsjogrenssyndrome AT sonalikhandelwal skinfindingsinapatientwithsjogrenssyndrome |