Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products
Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker co...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0003 |
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| author | Mbamalu Oluchi N. Syce James Samsodien Halima |
| author_facet | Mbamalu Oluchi N. Syce James Samsodien Halima |
| author_sort | Mbamalu Oluchi N. |
| collection | DOAJ |
| description | Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, and samples were analysed using a validated HPLC method. The dissolution profile of each marker varied for the different materials investigated. All three media utilised showed differences in flavonoid glycoside dissolution between the S. frutescens products evaluated, with f2 values < 50 for comparison of flavonoid dissolution from any two of the materials. Dissolution of S. frutescens materials could thus be characterised using the markers in all the media tested. This tool may be employed in the future for comparison of orally administered S. frutescens products, provided between- batch variability is evaluated and found less than between-sample variability. |
| format | Article |
| id | doaj-art-45b852efa83e4d14b4d16f1737012886 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-45b852efa83e4d14b4d16f17370128862025-02-02T08:32:25ZengSciendoActa Pharmaceutica1846-95582017-03-0167113714610.1515/acph-2017-0003acph-2017-0003Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens productsMbamalu Oluchi N.0Syce James1Samsodien Halima2Discipline of Pharmacology School of Pharmacy University of the Western Cape, Private Bag X17, Bellville 7535 Cape Town, South AfricaDiscipline of Pharmacology School of Pharmacy University of the Western Cape Private, Bag X17, Bellville 7535 Cape Town, South AfricaDiscipline of Pharmaceutics School of Pharmacy, University of the Western Cape, Private Bag X17 Bellville 7535, Cape Town, South AfricaUnlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, and samples were analysed using a validated HPLC method. The dissolution profile of each marker varied for the different materials investigated. All three media utilised showed differences in flavonoid glycoside dissolution between the S. frutescens products evaluated, with f2 values < 50 for comparison of flavonoid dissolution from any two of the materials. Dissolution of S. frutescens materials could thus be characterised using the markers in all the media tested. This tool may be employed in the future for comparison of orally administered S. frutescens products, provided between- batch variability is evaluated and found less than between-sample variability.https://doi.org/10.1515/acph-2017-0003sutherlandia frutescensherbal productsdissolution testingflavonoiddiscriminatory mediumsimilarity factor |
| spellingShingle | Mbamalu Oluchi N. Syce James Samsodien Halima Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products Acta Pharmaceutica sutherlandia frutescens herbal products dissolution testing flavonoid discriminatory medium similarity factor |
| title | Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products |
| title_full | Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products |
| title_fullStr | Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products |
| title_full_unstemmed | Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products |
| title_short | Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products |
| title_sort | challenges relating to comparison of flavonoid glycosides dissolution profiles from sutherlandia frutescens products |
| topic | sutherlandia frutescens herbal products dissolution testing flavonoid discriminatory medium similarity factor |
| url | https://doi.org/10.1515/acph-2017-0003 |
| work_keys_str_mv | AT mbamaluoluchin challengesrelatingtocomparisonofflavonoidglycosidesdissolutionprofilesfromsutherlandiafrutescensproducts AT sycejames challengesrelatingtocomparisonofflavonoidglycosidesdissolutionprofilesfromsutherlandiafrutescensproducts AT samsodienhalima challengesrelatingtocomparisonofflavonoidglycosidesdissolutionprofilesfromsutherlandiafrutescensproducts |