Generation of a homozygous ABCA7 knockout cell line (AHMUCNi002-A) in human iPSCs using CRISPR/Cas9

Generation of a homozygous ABCA7 knockout cell line (AHMUCNi002-A) in human iPSCs using CRISPR/Cas9

ABCA7, located on chromosome 19, encodes an ATP-binding cassette transporter. Loss-of-function variants of ABCA7 are associated with an increased risk of Alzheimer’s disease. To explore the role of ABCA7 deficiency in the pathogenesis of Alzheimer’s disease, CRISPR/Cas9 genome-editing technology was...

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Bibliographic Details
Main Authors: Juanjuan Li, Letian Yin, Chengwei Wang, Yin Xu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Stem Cell Research
Subjects:
ABCA7
CRISPR/Cas9
iPSCs
Alzheimer’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506125000509
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