The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD

The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD

Abstract Glomerular endothelial cells (GECs) are pivotal in developing glomerular sclerosis disorders. The advancement of focal segmental glomerulosclerosis (FSGS) is intimately tied to disruptions in lipid metabolism. Sphingosine-1-phosphate (S1P), a molecule transported by high-density lipoprotein...

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Main Authors: Yunfeng Xiong, Qiuping Ye, Lifang Liu, Wanjun Lin, Yonggen Liao, Ruiyu Gao, Jiaming Xu, Xinyu Zhang, Ruoyan Chen, Sihui Chen, Qiaoling Chen, Lixin Wei
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Sphingosine-1-phosphate
High-density lipoprotein
Glomerular endothelial cells
Focal segmental glomerulosclerosis
Minimal change disease
Online Access:https://doi.org/10.1038/s41598-025-85865-8
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https://doi.org/10.1038/s41598-025-85865-8

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