Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA‐Seq and Stereo‐Seq, with Insights into SOX3's Role in Pituitary Development

Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA‐Seq and Stereo‐Seq, with Insights into SOX3's Role in Pituitary Development

Abstract The 3D human pituitary organoid represents a promising laboratory model for investigating human pituitary diseases. Nonetheless, this technology is still in its nascent stage, with uncertainties regarding the cellular composition, intercellular interactions, and spatial distribution of the...

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Bibliographic Details
Main Authors: Shengjie Wang, Deyue Jiang, Yan Xiao, Qiaozhen Qin, Heyang Zhang, Lingtong Ye, Jide Jin, Xiaoxia Jiang, Qinghua Guo
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
organoids
pituitary
scRNA‐seq
SOX3
stereo‐seq
Online Access:https://doi.org/10.1002/advs.202414230
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https://doi.org/10.1002/advs.202414230

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