Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy

Abstract Immune cell metabolism plays a pivotal role in regulating cellular proliferation, differentiation, and functional responses, collectively shaping immune responses within the tumor microenvironment (TME). Recent advancements increasingly highlight diverse metabolic phenotypes of immune cells...

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Main Authors: Yingying Lv, Zongshang Li, Shutong Liu, Zhaokai Zhou, Jinling Song, Yuhao Ba, Siyuan Weng, Anning Zuo, Hui Xu, Peng Luo, Quan Cheng, Chuhan Zhang, Jingyuan Ning, Yukang Chen, Yuyuan Zhang, Zaoqu Liu, Xinwei Han
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Cancer
Subjects:
Immune cells
Metabolic checkpoints
Cancer immunotherapy
Tumor microenvironment
Metabolic reprogramming
T cell
Online Access:https://doi.org/10.1186/s12943-025-02407-6
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https://doi.org/10.1186/s12943-025-02407-6

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