The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia
Background: Severe pneumonia complicated by myocardial damage is a serious condition in children, and early prediction and intervention are crucial for improving outcomes. To explore the clinical value of serum hyaluronic acid, procollagen III N-terminal propeptide, sST2, and cfDNA levels in predict...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501141H.pdf |
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| author | Haoran Jia Ye Liu Tingting Zhao Dexing Wang Meng Du Weiwei Wang |
| author_facet | Haoran Jia Ye Liu Tingting Zhao Dexing Wang Meng Du Weiwei Wang |
| author_sort | Haoran Jia |
| collection | DOAJ |
| description | Background: Severe pneumonia complicated by myocardial damage is a serious condition in children, and early prediction and intervention are crucial for improving outcomes. To explore the clinical value of serum hyaluronic acid, procollagen III N-terminal propeptide, sST2, and cfDNA levels in predicting myocardial damage in children with severe pneumonia. Methods: A case-control study was conducted on 140 children with severe pneumonia, divided into a control group (n=70) and a group with disease complicated by myocardial injury (n=70). Biomarker levels (hyaluronic acid, procollagen III, N-terminal propeptide levels, sST2, and cfDNA) were detected through biochemical analysis, and clinical outcomes were compared between the two groups. Results: Logistic regression analysis identified hypoalbuminaemia, age <3 years, and elevated levels of serum hyaluronic acid, procollagen III N-terminal propeptide, sST2, and cfDNA as independent risk factors for myocardial damage. The AUC of these biomarkers in predicting myocardial injury ranged from 0.68 to 0.78, with sensitivities and specificities of 65-80%. The combined prediction AUC was 0.92, with a sensitivity of 87.6% and a specificity of 77%. The control group had lower serum NT-proBNP, CK, CK-MB, and C-reactive protein levels and better clinical outcomes than the myocardial injury group. Conclusions: Serum hyaluronic acid, procollagen III, NTproBNP, sST2, and cfDNA significantly predict severe pneumonia complicated by myocardial damage. Nursing strategies based on these biomarkers can effectively improve treatment outcomes, demonstrating significant clinical application value. |
| format | Article |
| id | doaj-art-451193f1d9174c0ea658d79f00b777cc |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-451193f1d9174c0ea658d79f00b777cc2025-02-05T13:11:23ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144114114710.5937/jomb0-512231452-82582501141HThe clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumoniaHaoran Jia0Ye Liu1Tingting Zhao2Dexing Wang3Meng Du4Weiwei Wang5Baoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology Department, Baoding, ChinaBaoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology Department, Baoding, ChinaBaoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology Department, Baoding, ChinaBaoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University, Pediatric Department, Baoding ChinaBaoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology Department, Baoding, ChinaBaoding Hospital, Beijing Children's Hospital Affiliated to Capital Medical University, Pediatric Department, Baoding ChinaBackground: Severe pneumonia complicated by myocardial damage is a serious condition in children, and early prediction and intervention are crucial for improving outcomes. To explore the clinical value of serum hyaluronic acid, procollagen III N-terminal propeptide, sST2, and cfDNA levels in predicting myocardial damage in children with severe pneumonia. Methods: A case-control study was conducted on 140 children with severe pneumonia, divided into a control group (n=70) and a group with disease complicated by myocardial injury (n=70). Biomarker levels (hyaluronic acid, procollagen III, N-terminal propeptide levels, sST2, and cfDNA) were detected through biochemical analysis, and clinical outcomes were compared between the two groups. Results: Logistic regression analysis identified hypoalbuminaemia, age <3 years, and elevated levels of serum hyaluronic acid, procollagen III N-terminal propeptide, sST2, and cfDNA as independent risk factors for myocardial damage. The AUC of these biomarkers in predicting myocardial injury ranged from 0.68 to 0.78, with sensitivities and specificities of 65-80%. The combined prediction AUC was 0.92, with a sensitivity of 87.6% and a specificity of 77%. The control group had lower serum NT-proBNP, CK, CK-MB, and C-reactive protein levels and better clinical outcomes than the myocardial injury group. Conclusions: Serum hyaluronic acid, procollagen III, NTproBNP, sST2, and cfDNA significantly predict severe pneumonia complicated by myocardial damage. Nursing strategies based on these biomarkers can effectively improve treatment outcomes, demonstrating significant clinical application value.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501141H.pdfserum hyaluronic acidprocollagen iiintprobnpsst2cfdnaguiding evidence-based nursingclinical value |
| spellingShingle | Haoran Jia Ye Liu Tingting Zhao Dexing Wang Meng Du Weiwei Wang The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia Journal of Medical Biochemistry serum hyaluronic acid procollagen iii ntprobnp sst2 cfdna guiding evidence-based nursing clinical value |
| title | The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia |
| title_full | The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia |
| title_fullStr | The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia |
| title_full_unstemmed | The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia |
| title_short | The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia |
| title_sort | clinical value of serum hyaluronic acid procollagen iii n terminal propeptide levels sst2 and cfdna in predicting the myocardial damage in children with severe pneumonia |
| topic | serum hyaluronic acid procollagen iii ntprobnp sst2 cfdna guiding evidence-based nursing clinical value |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501141H.pdf |
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