Ultra-sensitive in situ detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a

Ultra-sensitive in situ detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a

Mycobacterium tuberculosis (Mtb) invades and survives inside macrophages, evading detection and resisting antibiotic treatment, which results in severe clinical consequences such as fatal respiratory failure and systemic inflammation. Rapid and specific detection of intracellular Mtb is crucial for...

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Bibliographic Details
Main Authors: Zhiqiang Lin, Zhe Song, Hong Yu, Yang Zhou, Deliang Liu, Peize Zhang, Li Wei, Guiqin Dai, Guangyan Liang, Zhuojun He, Xiaorong Hu, Yuying Chen, Pengfei Zhao, Hongzhou Lu, Mingbin Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
mycobacterium tuberculosis
CRISPR/Cas12a
macrophage
intracellular detection
bronchoalveolar lavage fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597654/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597654/full

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