DNA methylomes undergo distinct waves of remodeling during thymic T cell development and do not acquire a proliferation-induced imprint

DNA methylomes undergo distinct waves of remodeling during thymic T cell development and do not acquire a proliferation-induced imprint

Summary: Dynamic changes of the DNA methylation (DNAmeth) landscape drive differentiation of mature T lymphocytes. However, the role of DNAmeth-mediated regulation in thymocyte development remains unclear. Thus, we generated genome-wide DNAmeth profiles of eight defined human thymocyte subsets, reve...

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Main Authors: Frederik Hamm, Emilie Coppin, Mingxing Yang, Alisier Malard, Anne Schulze, Marcel Finke, Dania Hamo, Abdulrahman Salhab, Gilles Gasparoni, Jörn Walter, Mir-Farzin Mashreghi, Joachim Photiadis, Claudia Waskow, Julia K. Polansky
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008630
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