GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation

GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation

BackgroundBone marrow (BM) suppression is the most prevalent dose-limiting side effect of chemotherapy and radiotherapy. Exposure to ionizing radiation (IR) results in acute BM suppression and long-term BM injury. Gasdermin E (GSDME) is crucial for mediating apoptosis and pyroptosis during chemother...

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Bibliographic Details
Main Authors: Lulu Su, Yinping Dong, Bowen Guan, Yuquan Wang, Yanhua Lu, Xinyue Wang, Wenxuan Li, Qidong Huo, Aimin Meng, Deguan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
GSDME
ionizing radiation
myeloid-biased differentiation
acute bone marrow suppression
long-term bone marrow injury
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1544320/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1544320/full

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