Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial
Purpose. To study the effect of 1-year daily consumption of a dairy drink containing lutein-enriched egg yolks on macular pigment optical density (MPOD) and visual function parameters in elderly subjects with ocular drusen and/or retinal pigment abnormalities. Methods. One hundred and one subjects w...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/9035745 |
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| author | Sanne M. van der Made Elton R. Kelly Aize Kijlstra Jogchum Plat Tos T. J. M. Berendschot |
| author_facet | Sanne M. van der Made Elton R. Kelly Aize Kijlstra Jogchum Plat Tos T. J. M. Berendschot |
| author_sort | Sanne M. van der Made |
| collection | DOAJ |
| description | Purpose. To study the effect of 1-year daily consumption of a dairy drink containing lutein-enriched egg yolks on macular pigment optical density (MPOD) and visual function parameters in elderly subjects with ocular drusen and/or retinal pigment abnormalities. Methods. One hundred and one subjects were recruited to participate in this randomized, double-blind, placebo-controlled parallel intervention trial. Statistical analyses were performed with 46 subjects in the lutein group and 43 in the control group. MPOD, best corrected visual acuity (BCVA, logMAR), and dark adaptation were measured at the start of the study, after 6 months and after 12 months. Plasma lutein and zeaxanthin concentrations were assessed at baseline and at the end of the study. Results. In the lutein group, plasma lutein concentrations increased significantly from 205 ng/mL at baseline to 399 ng/mL after twelve months of intervention. MPOD increased significantly from 0.45 to 0.52 and BCVA improved significantly from −0.04 to −0.09 LogMar. Differences in rod dark adaptation rate between both groups were not significant. Conclusion. Daily consumption of a dairy drink containing lutein-enriched egg yolks for one year improves visual acuity, MPOD, and plasma lutein concentration in elderly subjects with drusen and/or retinal pigment epithelial abnormalities. |
| format | Article |
| id | doaj-art-44dc47a71e7a4bce856c1b18e2369273 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-44dc47a71e7a4bce856c1b18e23692732025-02-03T05:50:15ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/90357459035745Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled TrialSanne M. van der Made0Elton R. Kelly1Aize Kijlstra2Jogchum Plat3Tos T. J. M. Berendschot4Department of Human Biology, NUTRIM School of Nutrition & Translational Research in Metabolism, Maastricht University Medical Centre, 6200 MD Maastricht, NetherlandsUniversity Eye Clinic Maastricht, Maastricht University Medical Centre, 6202 AZ Maastricht, NetherlandsUniversity Eye Clinic Maastricht, Maastricht University Medical Centre, 6202 AZ Maastricht, NetherlandsDepartment of Human Biology, NUTRIM School of Nutrition & Translational Research in Metabolism, Maastricht University Medical Centre, 6200 MD Maastricht, NetherlandsUniversity Eye Clinic Maastricht, Maastricht University Medical Centre, 6202 AZ Maastricht, NetherlandsPurpose. To study the effect of 1-year daily consumption of a dairy drink containing lutein-enriched egg yolks on macular pigment optical density (MPOD) and visual function parameters in elderly subjects with ocular drusen and/or retinal pigment abnormalities. Methods. One hundred and one subjects were recruited to participate in this randomized, double-blind, placebo-controlled parallel intervention trial. Statistical analyses were performed with 46 subjects in the lutein group and 43 in the control group. MPOD, best corrected visual acuity (BCVA, logMAR), and dark adaptation were measured at the start of the study, after 6 months and after 12 months. Plasma lutein and zeaxanthin concentrations were assessed at baseline and at the end of the study. Results. In the lutein group, plasma lutein concentrations increased significantly from 205 ng/mL at baseline to 399 ng/mL after twelve months of intervention. MPOD increased significantly from 0.45 to 0.52 and BCVA improved significantly from −0.04 to −0.09 LogMar. Differences in rod dark adaptation rate between both groups were not significant. Conclusion. Daily consumption of a dairy drink containing lutein-enriched egg yolks for one year improves visual acuity, MPOD, and plasma lutein concentration in elderly subjects with drusen and/or retinal pigment epithelial abnormalities.http://dx.doi.org/10.1155/2016/9035745 |
| spellingShingle | Sanne M. van der Made Elton R. Kelly Aize Kijlstra Jogchum Plat Tos T. J. M. Berendschot Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial Journal of Ophthalmology |
| title | Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full | Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_fullStr | Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full_unstemmed | Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_short | Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_sort | increased macular pigment optical density and visual acuity following consumption of a buttermilk drink containing lutein enriched egg yolks a randomized double blind placebo controlled trial |
| url | http://dx.doi.org/10.1155/2016/9035745 |
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