Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease
Background. The link between endogenous estrogen, coronary artery disease (CAD), and death in postmenopausal women is uncertain. We analyzed the association between death and blood levels of estrone in postmenopausal women with known coronary artery disease (CAD) or with a high-risk factor score for...
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/363595 |
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| author | Antonio de Padua Mansur Tereza Cristina B. F. Silva Julio Yoshio Takada Solange Desirée Avakian Célia Maria C. Strunz Luiz Antonio Machado César José Mendes Aldrighi José Antonio F. Ramires |
| author_facet | Antonio de Padua Mansur Tereza Cristina B. F. Silva Julio Yoshio Takada Solange Desirée Avakian Célia Maria C. Strunz Luiz Antonio Machado César José Mendes Aldrighi José Antonio F. Ramires |
| author_sort | Antonio de Padua Mansur |
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| description | Background. The link between endogenous estrogen, coronary artery disease (CAD), and death in postmenopausal women is uncertain. We analyzed the association between death and blood levels of estrone in postmenopausal women with known coronary artery disease (CAD) or with a high-risk factor score for CAD. Methods. 251 postmenopausal women age 50–90 years not on estrogen therapy. Fasting blood for estrone and heart disease risk factors were collected at baseline. Women were grouped according to their estrone levels (<15 and ≥15 pg/mL). Fatal events were recorded after 5.8±1.4 years of followup. Results. The Kaplan-Meier survival curve showed a significant trend (P=0.039) of greater all-cause mortality in women with low estrone levels (<15 pg/mL). Cox multivariate regression analysis model adjusted for body mass index, diabetes, dyslipidemia, family history, and estrone showed estrone (OR=0.45; P=0.038) as the only independent variable for all-cause mortality. Multivariate regression model adjusted for age, body mass index, hypertension, diabetes, dyslipidemia, family history, and estrone showed that only age (OR=1.06; P=0.017) was an independent predictor of all-cause mortality. Conclusions. Postmenopausal women with known CAD or with a high-risk factor score for CAD and low estrone levels (<15 pg/mL) had increased all-cause mortality. |
| format | Article |
| id | doaj-art-44da015fb4f84f03b6c5fa16b8f50b72 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-44da015fb4f84f03b6c5fa16b8f50b722025-02-03T05:53:55ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/363595363595Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery DiseaseAntonio de Padua Mansur0Tereza Cristina B. F. Silva1Julio Yoshio Takada2Solange Desirée Avakian3Célia Maria C. Strunz4Luiz Antonio Machado César5José Mendes Aldrighi6José Antonio F. Ramires7Heart Institute (InCor), University of São Paulo Medical School, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, 05403-000 São Paulo, SP, BrazilSchool of Public Health, University of São Paulo, 01246-904 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, 05403-000 São Paulo, SP, BrazilBackground. The link between endogenous estrogen, coronary artery disease (CAD), and death in postmenopausal women is uncertain. We analyzed the association between death and blood levels of estrone in postmenopausal women with known coronary artery disease (CAD) or with a high-risk factor score for CAD. Methods. 251 postmenopausal women age 50–90 years not on estrogen therapy. Fasting blood for estrone and heart disease risk factors were collected at baseline. Women were grouped according to their estrone levels (<15 and ≥15 pg/mL). Fatal events were recorded after 5.8±1.4 years of followup. Results. The Kaplan-Meier survival curve showed a significant trend (P=0.039) of greater all-cause mortality in women with low estrone levels (<15 pg/mL). Cox multivariate regression analysis model adjusted for body mass index, diabetes, dyslipidemia, family history, and estrone showed estrone (OR=0.45; P=0.038) as the only independent variable for all-cause mortality. Multivariate regression model adjusted for age, body mass index, hypertension, diabetes, dyslipidemia, family history, and estrone showed that only age (OR=1.06; P=0.017) was an independent predictor of all-cause mortality. Conclusions. Postmenopausal women with known CAD or with a high-risk factor score for CAD and low estrone levels (<15 pg/mL) had increased all-cause mortality.http://dx.doi.org/10.1100/2012/363595 |
| spellingShingle | Antonio de Padua Mansur Tereza Cristina B. F. Silva Julio Yoshio Takada Solange Desirée Avakian Célia Maria C. Strunz Luiz Antonio Machado César José Mendes Aldrighi José Antonio F. Ramires Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease The Scientific World Journal |
| title | Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease |
| title_full | Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease |
| title_fullStr | Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease |
| title_full_unstemmed | Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease |
| title_short | Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease |
| title_sort | long term prospective study of the influence of estrone levels on events in postmenopausal women with or at high risk for coronary artery disease |
| url | http://dx.doi.org/10.1100/2012/363595 |
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