MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHA
Background: Mosquito-borne parasites include the pathogenic protozoa and helminths that are transmitted by the insect vector which may co-infect with other organisms to elicit an immune response. Purpose: To determine the frequency of mosquito-borne parasites in patients newly infected with HIV in r...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Airlangga
2021-07-01
|
| Series: | Journal of Vocational Health Studies |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JVHS/article/view/27964 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571093464907776 |
|---|---|
| author | Mathew Folaranmi Olaniyan |
| author_facet | Mathew Folaranmi Olaniyan |
| author_sort | Mathew Folaranmi Olaniyan |
| collection | DOAJ |
| description | Background: Mosquito-borne parasites include the pathogenic protozoa and helminths that are transmitted by the insect vector which may co-infect with other organisms to elicit an immune response. Purpose: To determine the frequency of mosquito-borne parasites in patients newly infected with HIV in relationship with CD4 count and TNFα. Method: Thirty-one (31; aged 15-32 years; male-12; female-19) newly diagnosed HIV positive patients and fifty (50) age-matched HIV negative volunteers were recruited as a control subject for this study. All subjects were negative to anti-HCV/HBsAg ELISA, Plasmodium, Acid-Fast Bacilli (AFB) tests and the control subjects were also negative to HIVP24 Ag-Ab ELISA, Plasmodium spp. and Wuchereria bancrofti microscopy. Venous blood including Night blood samples and sputum samples were obtained from the participants for CD4 count by cyflowmetry, TNFα, HIVP24Ag-Ab, anti-HCV, HBsAg by ELISA and microscopic identification by Giemsa staining while Sputum sample was used for Ziehl Neelsen staining to demonstrate Acid Fast Bacilli (AFB). Result: A lower frequency of 25.8% (Rajan, 2008) Plasmodium spp. and 6.5% (James et al., 2015) W. bancrofti was obtained in newly infected HIV patients compared with 32% (Zeitlmann et al., 2001) Plasmodium spp. and 8% (WHO, 2019) W. bancrofti obtained in the non-HIV infected control subjects. Showed a significant decrease in CD4 count and increase in plasma TNFα in both HIV mono-infection and coinfection with Plasmodium spp. and W. bancrofti compared with the results obtained in the non-HIV infected control subjects (p<0.05) and the results obtained in the newly infected HIV patients without Plasmodium spp. and W. coinfection (p<0.05). Conclusion: There was a significant increase in plasma TNFα and a decrease in CD4 count in both HIV mono-infection and coinfection with Plasmodium spp. and W. bancrofti while a lower frequency of Plasmodium spp. and W. bancrofti was obtained in newly infected HIV patients compared with the results obtained in the non-HIV infected control subjects. |
| format | Article |
| id | doaj-art-44d83d54770b402e90743cd33e803a51 |
| institution | Kabale University |
| issn | 2580-7161 2580-717X |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Journal of Vocational Health Studies |
| spelling | doaj-art-44d83d54770b402e90743cd33e803a512025-02-02T13:08:16ZengUniversitas AirlanggaJournal of Vocational Health Studies2580-71612580-717X2021-07-0151586410.20473/jvhs.V5.I1.2021.58-6413164MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHAMathew Folaranmi Olaniyan0Edo State University Uzairue, NigeriaBackground: Mosquito-borne parasites include the pathogenic protozoa and helminths that are transmitted by the insect vector which may co-infect with other organisms to elicit an immune response. Purpose: To determine the frequency of mosquito-borne parasites in patients newly infected with HIV in relationship with CD4 count and TNFα. Method: Thirty-one (31; aged 15-32 years; male-12; female-19) newly diagnosed HIV positive patients and fifty (50) age-matched HIV negative volunteers were recruited as a control subject for this study. All subjects were negative to anti-HCV/HBsAg ELISA, Plasmodium, Acid-Fast Bacilli (AFB) tests and the control subjects were also negative to HIVP24 Ag-Ab ELISA, Plasmodium spp. and Wuchereria bancrofti microscopy. Venous blood including Night blood samples and sputum samples were obtained from the participants for CD4 count by cyflowmetry, TNFα, HIVP24Ag-Ab, anti-HCV, HBsAg by ELISA and microscopic identification by Giemsa staining while Sputum sample was used for Ziehl Neelsen staining to demonstrate Acid Fast Bacilli (AFB). Result: A lower frequency of 25.8% (Rajan, 2008) Plasmodium spp. and 6.5% (James et al., 2015) W. bancrofti was obtained in newly infected HIV patients compared with 32% (Zeitlmann et al., 2001) Plasmodium spp. and 8% (WHO, 2019) W. bancrofti obtained in the non-HIV infected control subjects. Showed a significant decrease in CD4 count and increase in plasma TNFα in both HIV mono-infection and coinfection with Plasmodium spp. and W. bancrofti compared with the results obtained in the non-HIV infected control subjects (p<0.05) and the results obtained in the newly infected HIV patients without Plasmodium spp. and W. coinfection (p<0.05). Conclusion: There was a significant increase in plasma TNFα and a decrease in CD4 count in both HIV mono-infection and coinfection with Plasmodium spp. and W. bancrofti while a lower frequency of Plasmodium spp. and W. bancrofti was obtained in newly infected HIV patients compared with the results obtained in the non-HIV infected control subjects.https://e-journal.unair.ac.id/JVHS/article/view/27964mosquito, plasmodium spp., wuchereria bancrofti newly infected hiv patients cd4 count, tnfα |
| spellingShingle | Mathew Folaranmi Olaniyan MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHA Journal of Vocational Health Studies mosquito, plasmodium spp., wuchereria bancrofti newly infected hiv patients cd4 count, tnfα |
| title | MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHA |
| title_full | MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHA |
| title_fullStr | MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHA |
| title_full_unstemmed | MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHA |
| title_short | MOSQUITO-BORNE PARASITES IN PATIENTS NEWLY INFECTED WITH HIV IN RELATIONSHIP WITH CD4 COUNT AND TNF ΑLPHA |
| title_sort | mosquito borne parasites in patients newly infected with hiv in relationship with cd4 count and tnf αlpha |
| topic | mosquito, plasmodium spp., wuchereria bancrofti newly infected hiv patients cd4 count, tnfα |
| url | https://e-journal.unair.ac.id/JVHS/article/view/27964 |
| work_keys_str_mv | AT mathewfolaranmiolaniyan mosquitoborneparasitesinpatientsnewlyinfectedwithhivinrelationshipwithcd4countandtnfalpha |