Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31
Employing the flexible hexacarboxylate ligand of 1,3,5-triazine-2,4,6-triamine hexaacetic acid (H6TTHA) to assemble with Co(NO3)2·6H2O, we have acquired a novel coordination compound, i.e., [Co2(H2TTHA)(H2O)]n·6n(H2O) (1). The analysis of single X-ray diffraction indicated that the H2TTHA2- ligand μ...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2021/2621863 |
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| author | Zhenshan Guo Jun Zhen Zhoujia Yao Yemeng Wang Chenlu Jin |
| author_facet | Zhenshan Guo Jun Zhen Zhoujia Yao Yemeng Wang Chenlu Jin |
| author_sort | Zhenshan Guo |
| collection | DOAJ |
| description | Employing the flexible hexacarboxylate ligand of 1,3,5-triazine-2,4,6-triamine hexaacetic acid (H6TTHA) to assemble with Co(NO3)2·6H2O, we have acquired a novel coordination compound, i.e., [Co2(H2TTHA)(H2O)]n·6n(H2O) (1). The analysis of single X-ray diffraction indicated that the H2TTHA2- ligand μ5-bridges connected the Co(II) ions into a two-dimensional layered architecture. Moreover, the magnetic property of 1 was also investigated between 2 and 300 K under 1000 Oe applied magnetic field. The novel compound’s inhibitory activity against the viability of cancer cell was determined through CCK-8 assay, and the expression of miRNA31 in liver cancer cells was detected via the real-time RT-PCR. |
| format | Article |
| id | doaj-art-44c0950b00294a83b09b4e2aa2d34f2e |
| institution | Kabale University |
| issn | 1687-9430 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-44c0950b00294a83b09b4e2aa2d34f2e2025-02-03T01:24:41ZengWileyInternational Journal of Polymer Science1687-94302021-01-01202110.1155/2021/2621863Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31Zhenshan Guo0Jun Zhen1Zhoujia Yao2Yemeng Wang3Chenlu Jin4Department of Hepatobiliary SurgeryDepartment of Hepatobiliary SurgeryDepartment of Hepatobiliary SurgeryDepartment of Hepatobiliary SurgeryDepartment of EndocrinologyEmploying the flexible hexacarboxylate ligand of 1,3,5-triazine-2,4,6-triamine hexaacetic acid (H6TTHA) to assemble with Co(NO3)2·6H2O, we have acquired a novel coordination compound, i.e., [Co2(H2TTHA)(H2O)]n·6n(H2O) (1). The analysis of single X-ray diffraction indicated that the H2TTHA2- ligand μ5-bridges connected the Co(II) ions into a two-dimensional layered architecture. Moreover, the magnetic property of 1 was also investigated between 2 and 300 K under 1000 Oe applied magnetic field. The novel compound’s inhibitory activity against the viability of cancer cell was determined through CCK-8 assay, and the expression of miRNA31 in liver cancer cells was detected via the real-time RT-PCR.http://dx.doi.org/10.1155/2021/2621863 |
| spellingShingle | Zhenshan Guo Jun Zhen Zhoujia Yao Yemeng Wang Chenlu Jin Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31 International Journal of Polymer Science |
| title | Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31 |
| title_full | Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31 |
| title_fullStr | Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31 |
| title_full_unstemmed | Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31 |
| title_short | Magnetic Property and Therapeutic Effect of a New Co(II) Complex on Liver Cancer by Regulating the Expression of miRNA31 |
| title_sort | magnetic property and therapeutic effect of a new co ii complex on liver cancer by regulating the expression of mirna31 |
| url | http://dx.doi.org/10.1155/2021/2621863 |
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