EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review
ABSTRACT We report a case showing that lorlatinib is effective in treating EML4‐ALK‐positive low‐grade serous ovarian cancer (LGSO) with intracranial metastasis. This may be the first clinical evidence of LGSO benefit from ALK inhibitors, to provide evidence for the use of ALK inhibitors in more ova...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70043 |
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| _version_ | 1832589901495795712 |
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| author | Qiongqian Li Tongze Cai Xiaoming Zheng Shunrong Zhang Chanjuan Li Huang Tang Zhiyong Yu Jianlong Zhou |
| author_facet | Qiongqian Li Tongze Cai Xiaoming Zheng Shunrong Zhang Chanjuan Li Huang Tang Zhiyong Yu Jianlong Zhou |
| author_sort | Qiongqian Li |
| collection | DOAJ |
| description | ABSTRACT We report a case showing that lorlatinib is effective in treating EML4‐ALK‐positive low‐grade serous ovarian cancer (LGSO) with intracranial metastasis. This may be the first clinical evidence of LGSO benefit from ALK inhibitors, to provide evidence for the use of ALK inhibitors in more ovarian cancer patients with EML4‐ALK fusion and promoting new ideas for the study of EML4‐ALK targets in ovarian cancer. |
| format | Article |
| id | doaj-art-44bb36b081224613a8d2a948464cb40f |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-44bb36b081224613a8d2a948464cb40f2025-01-24T05:08:46ZengWileyClinical Case Reports2050-09042025-01-01131n/an/a10.1002/ccr3.70043EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature ReviewQiongqian Li0Tongze Cai1Xiaoming Zheng2Shunrong Zhang3Chanjuan Li4Huang Tang5Zhiyong Yu6Jianlong Zhou7Department of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaDepartment of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaDepartment of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaDepartment of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaDepartment of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaDepartment of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaDepartment of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaDepartment of Oncology Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine Guangxi ChinaABSTRACT We report a case showing that lorlatinib is effective in treating EML4‐ALK‐positive low‐grade serous ovarian cancer (LGSO) with intracranial metastasis. This may be the first clinical evidence of LGSO benefit from ALK inhibitors, to provide evidence for the use of ALK inhibitors in more ovarian cancer patients with EML4‐ALK fusion and promoting new ideas for the study of EML4‐ALK targets in ovarian cancer.https://doi.org/10.1002/ccr3.70043EML4‐ALK fusion geneintracranial metastasislorlatinibovarian cancer |
| spellingShingle | Qiongqian Li Tongze Cai Xiaoming Zheng Shunrong Zhang Chanjuan Li Huang Tang Zhiyong Yu Jianlong Zhou EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review Clinical Case Reports EML4‐ALK fusion gene intracranial metastasis lorlatinib ovarian cancer |
| title | EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review |
| title_full | EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review |
| title_fullStr | EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review |
| title_full_unstemmed | EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review |
| title_short | EML4‐ALK‐Positive Ovarian Cancer With Intracranial Metastasis Responds to Lorlatinib: A Case Report and Literature Review |
| title_sort | eml4 alk positive ovarian cancer with intracranial metastasis responds to lorlatinib a case report and literature review |
| topic | EML4‐ALK fusion gene intracranial metastasis lorlatinib ovarian cancer |
| url | https://doi.org/10.1002/ccr3.70043 |
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