Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma
Abstract Background Inverted papilloma (IP) is an unusual type of benign tumor that has high recurrence rates and the potential to transform into squamous cell carcinomas (SCC). The mechanism of the transformation process from IP to IP-SCC is uncertain and there is no consensus regarding the best pr...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40463-020-00420-x |
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| _version_ | 1832544118404808704 |
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| author | Cai Long Basel Jabarin Alexandra Harvey Jennifer Ham Amin Javer Arif Janjua Andrew Thamboo |
| author_facet | Cai Long Basel Jabarin Alexandra Harvey Jennifer Ham Amin Javer Arif Janjua Andrew Thamboo |
| author_sort | Cai Long |
| collection | DOAJ |
| description | Abstract Background Inverted papilloma (IP) is an unusual type of benign tumor that has high recurrence rates and the potential to transform into squamous cell carcinomas (SCC). The mechanism of the transformation process from IP to IP-SCC is uncertain and there is no consensus regarding the best practice for IP-SCC detection. The goal of this study is to identify the best clinical methods to detect for IP-SCC. Methods An evidence-based review was performed using Medline and Ovid to obtain all articles up to October 10th, 2019 pertaining to identification of IP malignant transformation. All manuscripts discussing clinical methods or biomarkers were included. Results Based on clinical research studies, convoluted cerebriform pattern and apparent diffusion coefficient values on Magnetic Resonance Imaging (MRI) can help differentiate benign IP from SCC and increased SUVmax on PET/CT is associated with higher probability of malignancy although not as specific. No consensus about the best biomarker for IP-SCC has been reached among researchers and continues to be exploratory. Conclusion Endoscopy with biopsy is the gold standard practice to identify IP-SCC; however, MRI is the preferred imaging modality to recognize malignant transformation in cases where biopsy is difficult. Multiple biomarkers have shown positive results, but no single indicator with clinical significance for monitoring malignant transformation process has been found. |
| format | Article |
| id | doaj-art-44b4644091034e4d97c42290ec0b60c9 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-44b4644091034e4d97c42290ec0b60c92025-02-03T10:54:12ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162020-04-0149111110.1186/s40463-020-00420-xClinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papillomaCai Long0Basel Jabarin1Alexandra Harvey2Jennifer Ham3Amin Javer4Arif Janjua5Andrew Thamboo6Faculty of Medicine, University of British ColumbiaSt Paul’s Sinus Centre, University of British ColumbiaFaculty of Medicine, University of British ColumbiaFaculty of Medicine, University of British ColumbiaSt Paul’s Sinus Centre, University of British ColumbiaSt Paul’s Sinus Centre, University of British ColumbiaSt Paul’s Sinus Centre, University of British ColumbiaAbstract Background Inverted papilloma (IP) is an unusual type of benign tumor that has high recurrence rates and the potential to transform into squamous cell carcinomas (SCC). The mechanism of the transformation process from IP to IP-SCC is uncertain and there is no consensus regarding the best practice for IP-SCC detection. The goal of this study is to identify the best clinical methods to detect for IP-SCC. Methods An evidence-based review was performed using Medline and Ovid to obtain all articles up to October 10th, 2019 pertaining to identification of IP malignant transformation. All manuscripts discussing clinical methods or biomarkers were included. Results Based on clinical research studies, convoluted cerebriform pattern and apparent diffusion coefficient values on Magnetic Resonance Imaging (MRI) can help differentiate benign IP from SCC and increased SUVmax on PET/CT is associated with higher probability of malignancy although not as specific. No consensus about the best biomarker for IP-SCC has been reached among researchers and continues to be exploratory. Conclusion Endoscopy with biopsy is the gold standard practice to identify IP-SCC; however, MRI is the preferred imaging modality to recognize malignant transformation in cases where biopsy is difficult. Multiple biomarkers have shown positive results, but no single indicator with clinical significance for monitoring malignant transformation process has been found.http://link.springer.com/article/10.1186/s40463-020-00420-xInverted papillomaSinonasal inverted papillomaMalignancy transformationSquamous cell carcinomaSchniederian papillomaClinical surveillance |
| spellingShingle | Cai Long Basel Jabarin Alexandra Harvey Jennifer Ham Amin Javer Arif Janjua Andrew Thamboo Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma Journal of Otolaryngology - Head and Neck Surgery Inverted papilloma Sinonasal inverted papilloma Malignancy transformation Squamous cell carcinoma Schniederian papilloma Clinical surveillance |
| title | Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma |
| title_full | Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma |
| title_fullStr | Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma |
| title_full_unstemmed | Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma |
| title_short | Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma |
| title_sort | clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma |
| topic | Inverted papilloma Sinonasal inverted papilloma Malignancy transformation Squamous cell carcinoma Schniederian papilloma Clinical surveillance |
| url | http://link.springer.com/article/10.1186/s40463-020-00420-x |
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