Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes

Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes

Type 1 diabetes results from the destruction of pancreatic beta cells by autoreactive T cells. As an autoantigen with extremely high expression in beta cells, insulin triggers and sustains the autoimmune CD4+ and CD8+ T cell responses and islet inflammation. We have previously shown that deficiency...

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Bibliographic Details
Main Authors:	Marie-Andrée Bessard, Anna Moser, Emmanuelle Waeckel-Énée, Vivian Lindo, Abdelaziz Gdoura, Sylvaine You, F. Susan Wong, Fiona Greer, Peter van Endert
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Series:	Frontiers in Immunology
Subjects:	type 1 diabetes insulin antigen presentation antigen processing non-obese diabetic mouse CD8+ T cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1474453/full
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