Mechanisms of Staphylococcus aureus survival of trimethoprim-sulfamethoxazole-induced thymineless death

Mechanisms of Staphylococcus aureus survival of trimethoprim-sulfamethoxazole-induced thymineless death

ABSTRACT Trimethoprim-sulfamethoxazole (SXT) is commonly used to treat diverse Staphylococcus aureus infections, including those associated with cystic fibrosis (CF) pulmonary disease. Studies with Escherichia coli found that SXT impairs tetrahydrofolate production, leading to DNA damage, stress res...

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Main Authors: Lauren J. Gonsalves, Allyson Tran, Tessa Gardiner, Tiia Freeman, Angshita Dutta, Carson J. Miller, Sharon McNamara, Adam Waalkes, Dustin R. Long, Stephen J. Salipante, Lucas R. Hoffman, Daniel J. Wolter
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
Staphylococcus aureus
thymineless death
antibiotic resistance
antifolate drugs
persistence
Online Access:https://journals.asm.org/doi/10.1128/mbio.01634-24
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