Dapagliflozin effects on exercise, cardiac remodeling, biomarkers, and renal and pulmonary function in heart failure patients: not as good as expected?

Dapagliflozin effects on exercise, cardiac remodeling, biomarkers, and renal and pulmonary function in heart failure patients: not as good as expected?

BackgroundSodium-glucose cotransporter-2 inhibitors (SGLT2-i) are standard therapy for heart failure (HF). We performed a holistic evaluation of dapagliflozin, including its effects on exercise performance, left ventricle (LV) reverse remodeling, cardiac biomarkers, fluid retention, and renal and pu...

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Main Authors: Massimo Mapelli, Irene Mattavelli, Elisabetta Salvioni, Nicolò Capra, Valentina Mantegazza, Anna Garlaschè, Jeness Campodonico, Filippo Maria Rubbo, Chiara Paganin, Teresa Maria Capovilla, Alessandro Alberto Nepitella, Rebecca Caputo, Paola Gugliandolo, Carlo Vignati, Beatrice Pezzuto, Fabiana De Martino, Giulia Grilli, Marco Scatigna, Alice Bonomi, Gianfranco Sinagra, Manuela Muratori, Piergiuseppe Agostoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
dapagliflozin
SGLT2-i
heart failure
cardiopulmonary exercise testing (CPET)
reverse remodeling
HFrEF
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1542870/full
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https://www.frontiersin.org/articles/10.3389/fcvm.2025.1542870/full

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