Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA

Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA

Abstract Background Self-assembling peptides hold great promise for medical applications, particularly as carriers for gene delivery, but their potential remains unrealized due to a limited understanding of how amino acid sequence positioning affects their properties. In this study, we designed and...

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Bibliographic Details
Main Authors: Razieh Taghizadeh Pirposhteh, Nasir Mohajel, Arash Arashkia, Kayhan Azadmanesh, Mohammadali Masoumi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biotechnology
Subjects:
Amphiphilic peptides
Self-assembling peptides
Coarse-grained molecular dynamics simulation
Nonviral gene delivery
Alternating polarity
PH-responsive
Online Access:https://doi.org/10.1186/s12896-025-00976-4
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https://doi.org/10.1186/s12896-025-00976-4

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