Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples

Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples

Gene fusion events result in chimeric proteins that are frequently found in human cancers. Specific targeted therapies are available for several types of cancer fusions including receptor tyrosine kinase gene moieties. RNA sequencing (RNAseq) can directly be used for detection of gene rearrangements...

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Bibliographic Details
Main Authors:	Maxim Sorokin, Vladimir Lyadov, Maria Suntsova, Marat Garipov, Anna Semenova, Natalia Popova, Egor Guguchkin, Rustam Heydarov, Marianna Zolotovskaia, Xiaowen Zhao, Qing Yan, Ye Wang, Evgeny Karpulevich, Anton Buzdin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Molecular Biosciences
Subjects:	colorectal cancer formalin-fixed paraffin-embedded tumor tissue samples FFPE RNA sequencing RNAseq new cancer fusion genes
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1448792/full
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